Hafızoğlu Merve, Bas Arzu Okyar, Tavukçuoğlu Ece, Sahiner Zeynep, Oytun Merve Güner, Ulutürk Sıla, Yanık Hamdullah, Doğu Burcu Balam, Cankurtaran Mustafa, Esendağlı Güneş, Akbıyık Filiz, Çakır Banu, Ünal Serhat, Halil Meltem Gülhan
Department of Internal Medicine, Division of Geriatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Department of Basic Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Clin Immunol Commun. 2022 Dec;2:154-158. doi: 10.1016/j.clicom.2022.09.005. Epub 2022 Sep 29.
Generating memory T cell responses besides humoral immune responses is essential when it comes to the efficacy of a vaccine. In this study, the presence of memory T cell responses after aluminum-adjuvanted inactivated whole-virion SARS-CoV-2 vaccine (CoronaVac) in seronegative and seropositive elderly individuals were examined. CD4 and CD8 memory T cell proliferation and IFN-γ production capacities were evaluated. Additionally, clinical frailty scale (CFS) and FRAIL scales of the individuals were scored. CD4 memory T cell responses more prominent than CD8 memory T cells. In seronegative individuals, 80% of them had memory CD4 and IFN-γ, whereas 50% of them had memory CD4 and all of them had IFN-γ responses. Additionally, 40% of seronegative patients and 50% of seropositive patients had memory CD8 responses. To sum up, humoral immune responses are not associated with memory T cell responses, and in seronegative individuals, memory T cell responses can be detected.
就疫苗的效力而言，除了产生体液免疫反应外，产生记忆性T细胞反应也至关重要。在本研究中，检测了血清阴性和血清阳性老年个体接种铝佐剂灭活全病毒SARS-CoV-2疫苗（科兴新冠疫苗）后记忆性T细胞反应的情况。评估了CD4和CD8记忆性T细胞的增殖以及干扰素-γ的产生能力。此外，对个体的临床衰弱量表（CFS）和衰弱量表进行了评分。CD4记忆性T细胞反应比CD8记忆性T细胞反应更显著。在血清阴性个体中，80%的个体有记忆性CD4和干扰素-γ反应，而50%的个体有记忆性CD4反应，且所有个体都有干扰素-γ反应。此外，40%的血清阴性患者和50%的血清阳性患者有记忆性CD8反应。总之，体液免疫反应与记忆性T细胞反应无关，并且在血清阴性个体中可以检测到记忆性T细胞反应。
