Nazarova L S, Isupov I V, Pavlova L P, Gor'kova A V, Dushkin V A
Biull Eksp Biol Med. 1988 Jun;105(6):761-4.
The data obtained during the study of the morphological changes in the internal organs and blood of 6 mouse strains at the early stages of anti-plague immunity are presented. It has been established that the introduction of 5.10(3) and 1.10(5) m. b. of the EV vaccine strain resulted in the development of morphological changes typical of residual virulence. The degree of these changes depended on the haplotype of the animals and the dose used. The most resistant to injury induced by EV strain were CBA mice (haplotype H-2k) and the most sensitive were C57BL/6 mice (haplotype H-2b).
本文呈现了在抗鼠疫免疫早期阶段对6种小鼠品系的内脏器官和血液形态变化进行研究时所获得的数据。已确定，接种5×10³和1×10⁵个细菌的EV疫苗株会导致出现典型的残余毒力形态变化。这些变化的程度取决于动物的单倍型和所用剂量。对EV株诱导的损伤最具抵抗力的是CBA小鼠（单倍型H-2k），最敏感的是C57BL/6小鼠（单倍型H-2b）。
