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简化丙型肝炎治疗:消除丙型肝炎障碍的另一策略。

Simplified treatment of hepatitis C: another strategy to overcome the barriers to its elimination.

机构信息

Sección Hepatología, Departamento de Medicina, Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno, CEMIC, Buenos Aires, Argentina. E-mail:

Latin American Liver Research Educational and Awareness Network (LALREAN), Pilar, Buenos Aires, Argentina.

出版信息

Medicina (B Aires). 2021;81(2):252-256.

Abstract

The clinical management of hepatitis C virus (HCV) infection presents several challenges today. WHO's goal is to eliminate it by 2030. It is an ambitious goal and difficult to meet given the barriers to care that arise. This is possible today thanks to the discovery of direct-acting antivirals (DAAs). This treatment achieves a high cure rate and is virtually free of adverse effects. To try to comply with this, in addition to the use of DAAs, it is necessary to reduce the rate of undiagnosed patients and facilitate the access of those diagnosed to care and treatment. For that, it is proposed to carry out a simplified treatment of HCV. This involves reducing controls during and after treatment. This simplification varies according to whether patients have cirrhosis or not. In this way, it seeks to increase significantly the number of patients treated and cured to reduce the burden on public health of this disease.

摘要

目前,丙型肝炎病毒(HCV)感染的临床管理存在诸多挑战。世卫组织的目标是在 2030 年消除 HCV。这是一个雄心勃勃的目标,由于治疗过程中出现的各种障碍,难以实现。今天,直接作用抗病毒药物(DAA)的发现使这一目标成为可能。这种治疗方法可实现高治愈率,几乎没有不良反应。为了努力实现这一目标,除了使用 DAA 之外,还必须降低未确诊患者的比例,并为已确诊患者提供治疗和护理方面的便利。为此,建议简化 HCV 的治疗方法。这包括减少治疗期间和治疗后的检查次数。这种简化根据患者是否患有肝硬化而有所不同。通过这种方式,它旨在显著增加接受治疗和治愈的患者数量,以减轻该疾病对公共卫生的负担。

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