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俄罗斯消除丙型肝炎病毒:障碍与展望。

Elimination of HCV in Russia: Barriers and Perspective.

机构信息

Federal Research Centre of Nutrition, Biotechnology and Food Safety, Department of Gastroenterology & Hepatology, 109240 Moscow, Russia.

I. M. Sechenov First Moscow State Medical University, 119435 Moscow, Russia.

出版信息

Viruses. 2022 Apr 11;14(4):790. doi: 10.3390/v14040790.

DOI:10.3390/v14040790
PMID:35458520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9024583/
Abstract

Hepatitis C virus (HCV) is highly prevalent in Russia, representing the largest pool of hepatitis C patients in Europe. Effective treatment regimens with direct-acting antivirals can achieve HCV cure in all patients; therefore, in 2016 the World Health Organization proposed eliminating hepatitis C as a public health threat by 2030. However, only a small number of countries are on track to meet the WHO's hepatitis C elimination targets by 2030 due to many barriers in healthcare systems. This review focuses on a discussion about the epidemiology of HCV in Russia, the economic burden of HCV-related diseases, and treatment access with particular reference to the barriers for the elimination of HCV.

摘要

丙型肝炎病毒(HCV)在俄罗斯广泛流行,是欧洲最大的丙型肝炎患者群体。直接作用抗病毒药物的有效治疗方案可以使所有患者实现 HCV 治愈;因此,世界卫生组织于 2016 年提议到 2030 年消除丙型肝炎对公共卫生的威胁。然而,由于医疗体系中存在许多障碍,只有少数几个国家有望实现 2030 年消除丙型肝炎的世卫组织目标。本综述重点讨论了俄罗斯 HCV 的流行病学、HCV 相关疾病的经济负担以及特定治疗途径,特别提到了消除 HCV 的障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2297/9024583/f2cca993b228/viruses-14-00790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2297/9024583/f2cca993b228/viruses-14-00790-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2297/9024583/f2cca993b228/viruses-14-00790-g001.jpg

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本文引用的文献

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2
Global prevalence of hepatitis C virus in women of childbearing age in 2019: a modelling study.2019 年育龄期妇女丙型肝炎病毒全球流行率:一项建模研究。
Lancet Gastroenterol Hepatol. 2021 Mar;6(3):169-184. doi: 10.1016/S2468-1253(20)30359-9. Epub 2021 Jan 28.
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The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017.
Viruses. 2022 Jul 16;14(7):1554. doi: 10.3390/v14071554.
2017 年全球疾病负担研究:1990-2017 年 195 个国家和地区按病因划分的肝硬化全球、区域和国家负担:系统分析。
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Alcohol-Related Causes of Death and Drinking Patterns in Moldova as Compared to Russia and Ukraine.与俄罗斯和乌克兰相比,摩尔多瓦与酒精相关的死因及饮酒模式
Eur J Popul. 2017 Nov 21;33(5):679-700. doi: 10.1007/s10680-017-9450-4. eCollection 2017 Dec.
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Profile of hepatocellular carcinoma in the Republic of Moldova: first-hand information on the presentation, distribution and etiologies.摩尔多瓦共和国肝细胞癌概况:关于临床表现、分布及病因的第一手资料
Rom J Intern Med. 2019 Mar 1;57(1):37-46. doi: 10.2478/rjim-2018-0026.
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Hepatitis C in Eastern Europe and Central Asia: a survey of epidemiology, treatment access and civil society activity in eleven countries.东欧和中亚的丙型肝炎:对11个国家的流行病学、治疗可及性及民间社会活动的调查
Hepatol Med Policy. 2017 Jun 13;2:9. doi: 10.1186/s41124-017-0026-z. eCollection 2017.
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Lancet Gastroenterol Hepatol. 2017 Mar;2(3):161-176. doi: 10.1016/S2468-1253(16)30181-9. Epub 2016 Dec 16.
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