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二次神经胚形成过程中的细胞谱系、自我更新及上皮-间质转化

Cell Lineage, Self-Renewal, and Epithelial-to-Mesenchymal Transition during Secondary Neurulation.

作者信息

Kawachi Teruaki, Tadokoro Ryosuke, Takahashi Yoshiko

机构信息

Department of Zoology, Graduate School of Science, Kyoto University, Kyoto, Japan.

Faculty of Engineering, Okayama University of Science, Okayama, Japan.

出版信息

J Korean Neurosurg Soc. 2021 May;64(3):367-373. doi: 10.3340/jkns.2021.0054. Epub 2021 Apr 29.

DOI:10.3340/jkns.2021.0054
PMID:33906340
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8128514/
Abstract

Secondary neurulation (SN) is a critical process to form the neural tube in the posterior region of the body including the tail. SN is distinct from the anteriorly occurring primary neurulation (PN); whereas the PN proceeds by folding an epithelial neural plate, SN precursors arise from a specified epiblast by epithelial-to-mesenchymal transition (EMT), and undergo self-renewal in the tail bud. They finally differentiate into the neural tube through mesenchymal-to-epithelial transition (MET). We here overview recent progresses in the studies of SN with a particular focus on the regulation of cell lineage, self-renewal, and EMT/MET. Cellular mechanisms underlying SN help to understand the functional diversity of the tail in vertebrates.

摘要

继发性神经胚形成（SN）是在包括尾部在内的身体后部形成神经管的关键过程。SN与前部发生的原发性神经胚形成（PN）不同；PN通过上皮神经板折叠进行，而SN前体通过上皮-间充质转化（EMT）从特定的上胚层产生，并在尾芽中进行自我更新。它们最终通过间充质-上皮转化（MET）分化为神经管。我们在此概述SN研究的最新进展，特别关注细胞谱系、自我更新以及EMT/MET的调控。SN潜在的细胞机制有助于理解脊椎动物尾部的功能多样性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/61bac9e53c8b/jkns-2021-0054f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/84de950ed829/jkns-2021-0054f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/b0904ba08ecc/jkns-2021-0054f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/74e1e909369c/jkns-2021-0054f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/73209ee52aa4/jkns-2021-0054f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/61bac9e53c8b/jkns-2021-0054f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/84de950ed829/jkns-2021-0054f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/b0904ba08ecc/jkns-2021-0054f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/74e1e909369c/jkns-2021-0054f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/73209ee52aa4/jkns-2021-0054f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edc4/8128514/61bac9e53c8b/jkns-2021-0054f5.jpg

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