Klin Onkol. 2021 Spring;34(2):92-102. doi: 10.48095/ccko202192.
IgG4-related disease (IgG4-RD) is a non-malignant, chronic, immune-related disease. It was first recognized as a distinct disease in 2012 and the first classification criteria were published in 2020. This new entity can cause fibroinflammatory lesions in nearly any organ. It often presents as a multi-organ disease and can be confused with malignancy, infection or other immune-mediated conditions. Although the disease could affect virtually any organ, there are strong predilections for certain organs: the major salivary glands, the orbits and lacrimal glands, the pancreas and biliary tree, the lungs, the kidneys, the aorta and retroperitoneum, the meninges and the thyroid gland.
Correlation among clinical, serologic, radiologic and pathologic data is required for establishing IgG4-RD. We sum up the newest information necessary for the dia-gnosis.
IgG4 相关疾病（IgG4-RD）是一种非恶性、慢性、免疫相关疾病。它于 2012 年首次被确认为一种独特的疾病，2020 年首次发布了分类标准。这种新的实体可以在几乎任何器官中引起纤维炎症性病变。它常表现为多器官疾病，可能与恶性肿瘤、感染或其他免疫介导的疾病相混淆。虽然这种疾病几乎可以影响任何器官，但某些器官有强烈的倾向：主要唾液腺、眼眶和泪腺、胰腺和胆道、肺、肾、主动脉和腹膜后腔、脑膜和甲状腺。
为了确定 IgG4-RD，需要对临床、血清学、影像学和病理学数据进行相关性分析。我们总结了诊断所需的最新信息。
