Department of Burn and Plastic Surgery, General Hospital of Southern Theater Command, PLA, Guangzhou, Guangdong Province, China.
Medicine (Baltimore). 2021 Apr 30;100(17):e25650. doi: 10.1097/MD.0000000000025650.
Burns are still regarded among severe health problems related to high morbidity and mortality rates globally. In essence, health problems associated with burns can cause significant economic burden to society. Regardless of treatment available options, no best treatment was considered adequate for treating severe burns. In particular, only a few studies have focused on the effect of autologous platelet-rich plasma to treat burn wounds. The present study aim to systematically review existing literature to examine the effectiveness and safety of autologous platelet-rich plasma (PRP) to treat burn wounds.
For this study, we will conduct a systematic search using MEDLINE, EMBASE, the Cochrane Library, Web of Science, CINAHL, as well as Scopus to discover randomised controlled trials (RCTs) for the examination of effectiveness and safety of autologous PRP to treat burn wounds from their inception to March 2021 with no language restrictions. Additionally, we will search Google Scholar, ClinicalTrials.gov, as well as the reference lists of studies considered in the research to ascertain possibly eligible studies. We used two independent authors to evaluate studies for inclusion and conduct data extraction. We intend to assess study bias and quality utilizing the Cochrane Collaboration's Risk of Bias Tool 2.0. Also, we will pool study results using the fixed-effects model or random-effects model. Finally, any disagreements emanating from the process will be addressed through discussion or using a third author to mediate situations leading to disagreement.
The study aims at assessing the effectiveness and safety of autologous PRP for treating burn wounds.
The study will provide specific substantiation to assess autologous PRP's effectiveness and safety in treating patients with burn wounds.
The study does not require ethical approval since no published studies are used in it.
March 29, 2021.osf.io/74z5u. (https://osf.io/74z5u/).
烧伤仍然被认为是全球范围内与高发病率和死亡率相关的严重健康问题。从本质上讲，与烧伤相关的健康问题会给社会带来巨大的经济负担。无论可提供的治疗选择如何，都没有被认为足以治疗严重烧伤的最佳治疗方法。特别是，只有少数研究集中在自体富血小板血浆治疗烧伤创面的效果上。本研究旨在系统地回顾现有文献，以检查自体富血小板血浆（PRP）治疗烧伤创面的有效性和安全性。
在这项研究中，我们将使用 MEDLINE、EMBASE、Cochrane 图书馆、Web of Science、CINAHL 和 Scopus 进行系统搜索，以发现从成立到 2021 年 3 月期间，评估自体 PRP 治疗烧伤创面的有效性和安全性的随机对照试验（RCT），不限制语言。此外，我们还将搜索 Google Scholar、ClinicalTrials.gov 以及研究中考虑的研究参考文献，以确定可能符合条件的研究。我们使用两名独立的作者来评估纳入的研究并进行数据提取。我们打算使用 Cochrane 协作风险偏倚工具 2.0 来评估研究偏倚和质量。我们还将使用固定效应模型或随机效应模型汇总研究结果。最后，任何由此过程产生的分歧都将通过讨论或使用第三名作者来解决导致分歧的情况。
该研究旨在评估自体 PRP 治疗烧伤创面的有效性和安全性。
该研究将为评估自体 PRP 治疗烧伤患者的有效性和安全性提供具体依据。
该研究不需要伦理批准，因为其中不使用已发表的研究。
OSF 注册号：2021 年 3 月 29 日。osf.io/74z5u。（https://osf.io/74z5u/）。
