富血小板血浆治疗烧伤创面愈合的临床疗效：系统评价和荟萃分析方案。
Clinical therapeutic effects of platelet-rich plasma in patients with burn wound healing: A protocol for systematic review and meta-analysis.
机构信息
Department of Emergency Surgery, Tianyou Hospital Affiliated to Wuhan University of Science & Technology, Wuhan, Hubei, China.
Department of Critical Care Medicine, the First People's Hospital of Jiangxia District, Wuhan, Hubei, China.
出版信息
Medicine (Baltimore). 2021 Aug 6;100(31):e26404. doi: 10.1097/MD.0000000000026404.
BACKGROUND
In clinical settings, burn wounds are frequently encountered. Since burn wounds are a form of physical injury, they can have long-term adverse effects on the human body. It has been a significant challenge to treat burn wounds completely. Since traditional treatment strategies have been unable to heal burn wounds completely, they lack the efficacy to cure the wounds without long-term effects, such as heavy scarring. Reportedly, platelet-rich plasma (PRP) has shown potential to accelerate wound healing. Yet, there are no conclusive reports on a methodological comparative study of research that has assessed the medical benefits of PRP for treating individuals carrying burn wounds. Thus, the present meta-analysis and systematic study aims to assess the medical benefits of PRP for treating patients carrying burn wounds.
METHODS
The authors will conduct a comprehensive search for randomized controlled trials that evaluate the safeness and efficiency of PRP to treat burn wounds. The search includes 3 Chinese language databases (WanFang database, Chinese BioMedical Literature database, and China National Knowledge Infrastructure) and 4 English language databases (Cochrane Library, EMBASE, Web of Science, and MEDLINE). These electronic databases will be searched from their establishment till May 2021. A pair of independent authors will be selecting eligible studies for extracting data. The same authors will employ the Cochrane risk of bias tool to evaluate the bias risk. We will make use of RevMan (version: 5.3) software to complete data synthesis.
RESULTS
The present protocol will establish practical and targeted results evaluating the efficacy and safeness of using PRP to treat burn wounds. The current study also provides a reference for clinical use of PRP.
CONCLUSION
Stronger evidence about the effectiveness and safety of using PRP to treat and heal burn wounds will be provided for clinicians to refer.
ETHICS AND DISSEMINATION
Ethics approval is unrequired.
REGISTRATION NUMBER
March 31, 2021.osf.io/whauj. (https://osf.io/whauj/).
背景
在临床环境中，经常会遇到烧伤创面。由于烧伤创面是一种物理损伤，它们会对人体造成长期的不良影响。完全治愈烧伤创面一直是一个重大挑战。由于传统的治疗策略无法完全治愈烧伤创面，它们缺乏在没有长期影响（如严重疤痕）的情况下治愈创面的功效。据报道，富血小板血浆（PRP）在加速伤口愈合方面显示出了潜力。然而，对于评估 PRP 治疗烧伤患者的医学益处的研究，还没有关于方法学比较研究的结论性报告。因此，本荟萃分析和系统研究旨在评估 PRP 治疗烧伤患者的医学益处。
方法
作者将全面检索评估 PRP 治疗烧伤创面的安全性和有效性的随机对照试验。检索包括 3 个中文数据库（万方数据库、中国生物医学文献数据库和中国国家知识基础设施）和 4 个英文数据库（Cochrane 图书馆、EMBASE、Web of Science 和 MEDLINE）。这些电子数据库将从建立到 2021 年 5 月进行搜索。一对独立的作者将选择合格的研究进行数据提取。同一作者将采用 Cochrane 偏倚风险工具评估偏倚风险。我们将使用 RevMan（版本：5.3）软件完成数据合成。
结果
本方案将建立评估 PRP 治疗烧伤创面的疗效和安全性的实用和有针对性的结果。目前的研究也为 PRP 的临床应用提供了参考。
结论
将为临床医生提供关于使用 PRP 治疗和治愈烧伤创面的有效性和安全性的更强证据。
伦理和传播
不需要伦理批准。
注册号
2021 年 3 月 31 日。osf.io/whauj.（https://osf.io/whauj/）。
Zotero 插件