Huaibei Traditional Chinese Medicine Hospital.
Jiangxi University of Traditional Chinese Medicine.
Medicine (Baltimore). 2021 Apr 30;100(17):e25744. doi: 10.1097/MD.0000000000025744.
Gastric ulcer (GU) is a common digestive system disease, and the main clinical manifestations are nausea and epigastric pain. In recent years, due to increased life pressure, unhealthy eating habits and environment, the incidence of gastric ulcer has increased year by year. Because the disease has a long treatment cycle and is prone to relapse, if it cannot be controlled in time, it can cause the disease to prolong, affect the daily life and health of the patient, and even cause complications such as upper gastrointestinal bleeding, ulcer perforation, and pyloric obstruction. Helicobacter pylori infection is one of the main causes of GU. Clinically, the curative effect of western medicine or traditional Chinese medicine cannot reach the ideal level, so in recent years, the combination of traditional Chinese and western medicine has been highly praised. The aim of this systematic review is to evaluate the effectiveness and safety of Chinese medicine combined with omeprazole for GU.
The data and information will be retrieved from the databases of PubMed, Embase, Cochrane Library, CNKI, VIP, and Wanfang data. Literature search is limited to Chinese and English. The search time range is from the establishment of the database to April 7, 2021. The search strategy uses a combination of subject terms and free words to search. In order to avoid omissions, the search scope includes subject terms, keywords, or full text. Two reviewers will independently exclude substandard articles and extract eligible data. The risk of bias will be assessed using the Cochrane Handbook 5.1.0 for Systematic Reviews of Interventions. RevMan 5.3 will be used for systematic review and meta-analysis. This protocol will be reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols (PRISMA-P) statement, and the systematic review will be reported with the PRISMA statement.
The efficacy and safety of Chinese medicine combined with omeprazole for the treatment of GU will be evaluated, and the conclusion will be published to provide medical evidence for a better clinical decision of patients with GU.
胃溃疡（GU）是一种常见的消化系统疾病，主要临床表现为恶心和上腹痛。近年来，由于生活压力增加、不健康的饮食习惯和环境，胃溃疡的发病率逐年上升。由于该病治疗周期长且易复发，如果不能及时控制，可使病情迁延，影响患者的日常生活和健康，甚至可引起上消化道出血、溃疡穿孔、幽门梗阻等并发症。幽门螺杆菌感染是 GU 的主要病因之一。临床上，西药或中药的疗效均不能达到理想水平，因此近年来，中西医结合受到高度评价。本系统评价旨在评估中药联合奥美拉唑治疗 GU 的疗效和安全性。
数据和信息将从 PubMed、Embase、Cochrane 图书馆、中国知网、维普、万方数据等数据库中检索。文献检索仅限于中文和英文。检索时间范围为从数据库建立到 2021 年 4 月 7 日。检索策略采用主题词和自由词相结合的方式进行检索。为避免遗漏，检索范围包括主题词、关键词或全文。两位审查员将独立剔除不符合标准的文章并提取合格数据。使用 Cochrane 干预措施系统评价手册 5.1.0 评估偏倚风险。RevMan 5.3 将用于系统评价和荟萃分析。本方案将按照系统评价和荟萃分析报告的首选报告项目（PRISMA-P）声明进行报告，并按照 PRISMA 声明报告系统评价。
将评估中药联合奥美拉唑治疗 GU 的疗效和安全性，并发表结论，为 GU 患者的更好临床决策提供医学证据。
