用于治疗视网膜疾病的抗氧化剂：近期证据总结
Antioxidants for the Treatment of Retinal Disease: Summary of Recent Evidence.
作者信息
Wang Patrick, Chin Eric K, Almeida David
机构信息
School of Medicine, Queen's University, Kingston, Ontario, Canada.
Retina Consultants of Southern California, Redlands, CA, USA.
出版信息
Clin Ophthalmol. 2021 Apr 19;15:1621-1628. doi: 10.2147/OPTH.S307009. eCollection 2021.
Abstract
Retinal tissue is prone to oxidant burden and oxidative stress secondary to the generation of reactive oxygen species from high metabolic demand. The formation of reactive oxygen species occurs primarily from the mitochondrial respiratory chain as well as several enzymatic and oxidation reactions that occur in the neurosensory retina and retinal pigment epithelium. This oxidative stress has been implicated in the pathogenesis of several retinal diseases and the role of antioxidants as a therapeutic treatment shows promise in slowing the progression of certain diseases. The aim of this narrative review is to describe the mechanisms of retinal oxidative stress and summarize the current available evidence for antioxidants as a treatment for vitreoretinal disorders.
摘要
视网膜组织因高代谢需求产生活性氧而容易受到氧化负担和氧化应激的影响。活性氧的形成主要发生在线粒体呼吸链以及神经感觉视网膜和视网膜色素上皮中发生的几种酶促和氧化反应。这种氧化应激与几种视网膜疾病的发病机制有关，抗氧化剂作为一种治疗方法在减缓某些疾病进展方面显示出前景。本叙述性综述的目的是描述视网膜氧化应激的机制，并总结目前关于抗氧化剂治疗玻璃体视网膜疾病的现有证据。
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AAPS PharmSciTech. 2020 Oct 21;21(8):291. doi: 10.1208/s12249-020-01836-4.
2
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Asia Pac J Clin Nutr. 2019;28(3):607-613. doi: 10.6133/apjcn.201909_28(3).0021.
3
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7
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