Best Anton, Rambarran Nastassia
Ministry of Health and Wellness Bridgetown Barbados Ministry of Health and Wellness, Bridgetown, Barbados.
Independent researcher Independent researcher.
Rev Panam Salud Publica. 2021 Apr 23;45:e51. doi: 10.26633/RPSP.2021.51. eCollection 2021.
To assess the demographics, risk profiles and outcome indicators of one of the few government-supported programs on pre-exposure prophylaxis (PrEP) in the English-speaking Caribbean.
Chart review of all persons enrolled into the national PrEP Program from its inception on March 1 2018 to November 30 2019, with a descriptive summary analysis of the data extracted.
Of the 134 persons enrolled into the program most identified as men who have sex with men (67.9%), followed by men who have sex with men and women (14.9%); there were 20 persons, mostly men (85%), in sero-discordant relationships. PrEP uptake was 96%; however, the continuation rate (continuing for three consecutive months after initiation) was 61.5%. Continuation status for many could not be ascertained due to loss-to-follow-up. PrEP-associated toxicity prevalence was 2.3%, although side-effects occurred in 52% (mostly gastrointestinal). HIV positivity during the study period was 1.5%.
Uptake of Barbados' national PrEP Program is excellent but fairly low continuation rates and the HIV positivity rate indicate the need for improved pre-ART initiation education and follow-up processes. Service utilisation is mainly by men who have sex with men, and provision expansion to other civil society partners and private practitioners, as well as increased public awareness could increase access by other high-risk groups.
评估加勒比英语地区少数几个政府支持的暴露前预防(PrEP)项目之一的人口统计学特征、风险状况和结果指标。
对2018年3月1日项目启动至2019年11月30日期间纳入国家PrEP项目的所有人员进行病历审查,并对提取的数据进行描述性总结分析。
在134名登记参加该项目的人员中,大多数被认定为男男性行为者(67.9%),其次是男女性行为者(14.9%);有20人处于血清学不一致关系中,其中大多数是男性(85%)。PrEP的使用率为96%;然而,持续率(开始后连续三个月持续使用)为61.5%。由于失访,许多人的持续状态无法确定。PrEP相关毒性患病率为2.3%,尽管52%的人出现了副作用(主要是胃肠道副作用)。研究期间的HIV阳性率为1.5%。
巴巴多斯国家PrEP项目的使用率很高,但持续率相当低,HIV阳性率表明需要改进抗逆转录病毒治疗启动前的教育和随访流程。服务主要由男男性行为者使用,扩大向其他民间社会伙伴和私人从业者的服务提供,以及提高公众意识,可以增加其他高危人群的可及性。