Garrido Carolina, Hurst Jillian H, Lorang Cynthia G, Aquino Jhoanna N, Rodriguez Javier, Pfeiffer Trevor S, Singh Tulika, Semmes Eleanor C, Lugo Debra J, Rotta Alexandre T, Turner Nicholas A, Burke Thomas W, McClain Micah T, Petzold Elizabeth A, Permar Sallie R, Moody M Anthony, Woods Christopher W, Kelly Matthew S, Fouda Genevieve G
medRxiv. 2021 Apr 20:2021.04.17.21255663. doi: 10.1101/2021.04.17.21255663.
As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or mild symptomatic SARS-CoV-2 infection. We detected robust IgM, IgG, and IgA antibody responses to a broad array of SARS-CoV-2 antigens at the time of acute infection and 2 and 4 months after acute infection in all participants. Notably, these antibody responses were associated with virus neutralizing activity that was still detectable 4 months after acute infection in 94% of children. Moreover, antibody responses and neutralizing activity in sera from children and adolescents were comparable or superior to those observed in sera from 24 adults with mild symptomatic infection. Taken together, these findings indicate children and adolescents with mild or asymptomatic SARS-CoV-2 infection generate robust and durable humoral immune responses that are likely to protect from reinfection.
随着严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在全球持续传播，特定人群免疫反应的强度和持久性问题日益凸显。在本研究中，我们评估了69例无症状或轻症SARS-CoV-2感染儿童及青少年的体液免疫反应。在所有参与者急性感染时、急性感染后2个月和4个月，我们检测到针对多种SARS-CoV-2抗原的强烈IgM、IgG和IgA抗体反应。值得注意的是，这些抗体反应与病毒中和活性相关，在94%的儿童中，急性感染后4个月仍可检测到病毒中和活性。此外，儿童和青少年血清中的抗体反应及中和活性与24例轻症感染成人血清中观察到的反应相当或更优。综上所述，这些发现表明，轻症或无症状SARS-CoV-2感染的儿童和青少年可产生强烈且持久的体液免疫反应，这可能会预防再次感染。
