[Preliminary clinical study on the effect of metformin on prognosis of patients with oral squamous cell carcinoma after surgical treatment].

PURPOSE

To investigate the effect of metformin on the prognosis of patients with oral squamous cell carcinoma after surgical treatment.

METHODS

Three hundred and forty-six patients with oral squamous cell carcinoma after operation in Xiangya Hospital of Central South University from October 2015 to October 2016 were selected and divided into experimental group and control group. In the experimental group, 71 patients with oral squamous cell carcinoma received metformin after surgery. The control group included 275 patients without metformin after surgery of oral squamous cell carcinoma. The clinical follow-up results of patients in the two groups were compared. SPSS 21.0 software package was used to analyze the data.

RESULTS

Compared with the control group, the recurrent rate of the experimental group was lower. The difference was more significant in male patients, patients with primary tongue tumor, patients with highly differentiated squamous cell carcinoma, patients with cervical lymph node metastasis, and patients with a history of chewing areca nut (P<0.05).

CONCLUSIONS

Metformin can decrease postoperative recurrent rate and metastatic rate of oral squamous cell carcinoma after surgery.