Huang Dan-Ni, Chen Wen-Xin, Xiong Hao-Feng, Hu Xin, Mao Ting, Su Tong
Centre of Stomatology, Xiangya Hospital, Central South University. Changsha 410008, China. E-mail:
Shanghai Kou Qiang Yi Xue. 2021 Feb;30(1):61-65.
To investigate the effect of metformin on the prognosis of patients with oral squamous cell carcinoma after surgical treatment.
Three hundred and forty-six patients with oral squamous cell carcinoma after operation in Xiangya Hospital of Central South University from October 2015 to October 2016 were selected and divided into experimental group and control group. In the experimental group, 71 patients with oral squamous cell carcinoma received metformin after surgery. The control group included 275 patients without metformin after surgery of oral squamous cell carcinoma. The clinical follow-up results of patients in the two groups were compared. SPSS 21.0 software package was used to analyze the data.
Compared with the control group, the recurrent rate of the experimental group was lower. The difference was more significant in male patients, patients with primary tongue tumor, patients with highly differentiated squamous cell carcinoma, patients with cervical lymph node metastasis, and patients with a history of chewing areca nut (P<0.05).
Metformin can decrease postoperative recurrent rate and metastatic rate of oral squamous cell carcinoma after surgery.
探讨二甲双胍对口腔鳞状细胞癌患者手术治疗后预后的影响。
选取2015年10月至2016年10月在中南大学湘雅医院接受手术治疗的346例口腔鳞状细胞癌患者，分为实验组和对照组。实验组71例口腔鳞状细胞癌患者术后服用二甲双胍。对照组包括275例口腔鳞状细胞癌术后未服用二甲双胍的患者。比较两组患者的临床随访结果。采用SPSS 21.0软件包进行数据分析。
与对照组相比，实验组的复发率较低。在男性患者、原发性舌肿瘤患者、高分化鳞状细胞癌患者、颈部淋巴结转移患者以及有嚼槟榔史的患者中差异更为显著（P<0.05）。
二甲双胍可降低口腔鳞状细胞癌术后的复发率和转移率。
