Keller S M, Groshen S, Martini N, Kaiser L R
Division of Thoracic Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
Cancer. 1988 Aug 1;62(3):606-10. doi: 10.1002/1097-0142(19880801)62:3<606::aid-cncr2820620327>3.0.co;2-q.
Recent reports have suggested that perioperative blood transfusions may adversely affect prognosis after resection of non-small cell lung cancer (NSCLC). To determine the impact of perioperative transfusion on the recurrence-free interval, the status of 352 patients who underwent pulmonary resection for pathologic Stages I and II NSCLC was investigated. Transfused patients were significantly older than untransfused patients (P = 0.0009) but were not significantly different in sex distribution (P = 0.12) or tumor stage (P = 0.09). Recurrence was not significantly different in transfused patients when compared with patients who received no blood (P = 0.23) even when stratified for stage (Stage I, P = 0.58; Stage II, P = 0.14). Furthermore, the number of units transfused was not associated with time to tumor recurrence (P = 0.58). Contrary to other reports, these results do not support the contention that perioperative blood transfusion is significantly associated with decreased recurrence-free survival.
近期报告表明，围手术期输血可能对非小细胞肺癌（NSCLC）切除术后的预后产生不利影响。为确定围手术期输血对无复发生存期的影响，对352例行肺切除术的Ⅰ期和Ⅱ期NSCLC患者的情况进行了调查。输血患者明显比未输血患者年龄大（P = 0.0009），但在性别分布（P = 0.12）或肿瘤分期（P = 0.09）方面无显著差异。与未输血患者相比，输血患者的复发情况无显著差异（P = 0.23），即使按分期分层（Ⅰ期，P = 0.58；Ⅱ期，P = 0.14）也是如此。此外，输血量与肿瘤复发时间无关（P = 0.58）。与其他报告相反，这些结果不支持围手术期输血与无复发生存期缩短显著相关的观点。
