Jakobsen E B, Eickhoff J H, Andersen J, Lundvall L, Stenderup J K
Dept. of Surgery K, Frederiksberg Hospital, Denmark.
Scand J Gastroenterol. 1990 May;25(5):435-42. doi: 10.3109/00365529009095512.
Several reports have claimed that perioperative blood transfusion promotes recurrence and death after cancer surgery. We studied the effect of transfusion in 315 patients who had radical resection for carcinoma of the colon and rectum. The disease recurred in 113 (42%) of 268 transfused patients, versus in 15 (32%) in 47 non-transfused patients (P = 0.2). Of the transfused patients 102 (38%) died of colon cancer, versus 13 patients (28%) in the non-transfused group (P = 0.2). The 5-year recurrence-free survival rate was 0.59 in the transfused patients and 0.72 in the non-transfused group (P = 0.10). When differences in confounding background variables were accounted for by Cox multiple regression analysis, the significance of transfusion was even less. The study does not support the hypothesis that perioperative blood transfusion promotes recurrence after operation for colorectal cancer.
有几份报告称，围手术期输血会促使癌症手术后复发和死亡。我们研究了输血对315例行结肠癌和直肠癌根治性切除术患者的影响。268例输血患者中有113例（42%）疾病复发，而47例未输血患者中有15例（32%）复发（P = 0.2）。输血患者中有102例（38%）死于结肠癌，未输血组有13例（28%）（P = 0.2）。输血患者的5年无复发生存率为0.59，未输血组为0.72（P = 0.10）。当通过Cox多元回归分析考虑混杂背景变量的差异时，输血的显著性更低。该研究不支持围手术期输血会促使结直肠癌手术后复发这一假设。
