State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Research Center of Medical Sciences & Department of Radiology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China.
ACS Appl Mater Interfaces. 2021 May 12;13(18):21097-21107. doi: 10.1021/acsami.1c05517. Epub 2021 Apr 28.
Nanobubbles (NBs) have recently gained interest in cancer imaging and therapy due to the fact that nanoparticles with the size range of 1-1000 nm can extravasate into permeable tumor types through the enhanced permeability and retention (EPR) effect. However, the therapeutic study of NBs was only limited to drug delivery or cavitation. Herein, we developed ultrasound-evoked massive NB explosion to strikingly damage the surrounding cancer. The dual-function agent allows synergistic mechanical impact and photodynamic therapy of the tumors and enhances imaging contrast. Moreover, the mechanical explosion improved the light delivery efficiency in biological tissue to promote the effect of photodynamic therapy. Under ultrasound/photoacoustic imaging guidance, we induced on-the-spot bubble explosion and photodynamic therapy of tumors at a depth of centimeters . The mechanical impact of the explosion can enhance delivery of the photosensitizers. Ultrasound explicitly revealed the cancer morphology and exhibited fast NB perfusion. Generated mechanical damage and release of mixture agents demonstrated remarkable synergetic anticancer effects on deep tumors. This finding also offers a new approach and insight into treating cancers.
纳米气泡 (NBs) 由于其尺寸范围在 1-1000nm 的纳米颗粒可以通过增强的通透性和保留 (EPR) 效应渗透到通透性肿瘤类型中，最近在癌症成像和治疗方面引起了关注。然而，NBs 的治疗研究仅局限于药物输送或空化。在此，我们开发了超声诱发的大量 NB 爆炸，以显著破坏周围的癌症。双功能试剂允许协同的机械冲击和光动力治疗肿瘤，并增强成像对比度。此外，机械爆炸提高了生物组织中的光传输效率，以促进光动力治疗的效果。在超声/光声成像引导下，我们在厘米深度处诱导了肿瘤的现场气泡爆炸和光动力治疗。爆炸的机械冲击可以增强光敏剂的传递。超声明确显示了癌症形态，并表现出快速的 NB 灌注。产生的机械损伤和混合试剂的释放对深部肿瘤表现出显著的协同抗癌作用。这一发现也为治疗癌症提供了一种新的方法和思路。
