严重炎症、急性肾损伤和药物相互作用：COVID-19 患者阿哌沙班清除时间延长的三重惩罚：一个大查房。
Severe Inflammation, Acute Kidney Injury, and Drug-Drug Interaction: Triple Penalty for Prolonged Elimination of Apixaban in Patients With Coronavirus Disease 2019: A Grand Round.
机构信息
Laboratoire de Pharmacologie-Toxicologie-Gaz du Sang, CHU de Saint-Etienne, Saint Etienne, France.
Service de Médecine Intensive et Réanimation G, CHU de Saint-Etienne, Saint Etienne, France.
出版信息
Ther Drug Monit. 2021 Aug 1;43(4):455-458. doi: 10.1097/FTD.0000000000000899.
In this article, we present a case of apixaban elimination prolonged by 450% in a patient with coronavirus disease 2019 because of multiple conditions, including drug-drug interaction, severe inflammation, and acute kidney injury. Therapeutic drug monitoring was used to explain unusual routine coagulation assays. This grand round highlights the importance of dialog between the clinician and a therapeutic drug monitoring consultant for optimal patient care.
在这篇文章中，我们报告了一例新冠肺炎患者由于多种情况（包括药物相互作用、严重炎症和急性肾损伤）导致阿哌沙班消除延长 450%的病例。治疗药物监测用于解释不寻常的常规凝血检测。这个病例强调了临床医生和治疗药物监测顾问之间进行对话以实现最佳患者护理的重要性。
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