-NO 修饰的 Ru(II) 配合物诱导的光致线粒体 DNA 损伤和 NADH 耗竭。
Photo-induced mitochondrial DNA damage and NADH depletion by -NO modified Ru(II) complexes.
机构信息
Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
出版信息
Chem Commun (Camb). 2021 Apr 27;57(34):4162-4165. doi: 10.1039/d1cc00258a.
Two mitochondria-localized Ru(ii) complexes with photo-labile ligands were reported to exert one- and two-photon activatable anticancer activity through a dual-function mechanism, i.e. mitochondrial DNA covalent binding after photo-induced ligand dissociation and photo-catalyzed NADH depletion, thus displaying good activity towards cisplatin-resistant cancer cells under both normoxic and hypoxic conditions.
两种定位于线粒体的 Ru(ii) 配合物具有光不稳定配体，通过双重功能机制发挥一和双光子激活抗癌活性，即在光诱导配体解离后与线粒体 DNA 共价结合以及光催化 NADH 耗竭，因此在常氧和缺氧条件下对顺铂耐药癌细胞均显示出良好的活性。
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