Asal N R, Risser D R, Kadamani S, Geyer J R, Lee E T, Cherng N
Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City 73190.
Cancer Detect Prev. 1988;11(3-6):359-77.
Potential risk factors in renal cell carcinoma (RCC) were studied in a case-control study of 315 RCC cases, 313 hospital and 336 population controls. Risk factors included body mass index, education, smoking, beverage use, and artificial sweeteners. High body mass index, when present at age 20 and maintained, was a significant risk factor in both men and women. The lower the educational levels attained, the higher the risk. There was a weak positive association with cigarette smoking, coffee drinking, tea drinking, and decaffeinated coffee. A strong negative association was found with ever use of alcohol and it was strongest for wine. A positive association was found with use of artificial sweeteners in men. These findings have increased our understanding of the etiology of this rare but increasingly important neoplastic disease in humans.
在一项病例对照研究中，对315例肾细胞癌（RCC）病例、313例医院对照和336例人群对照进行了RCC潜在风险因素的研究。风险因素包括体重指数、教育程度、吸烟、饮料摄入及人工甜味剂。20岁时即存在且持续的高体重指数是男性和女性的显著风险因素。受教育程度越低，风险越高。吸烟、饮用咖啡、茶及脱咖啡因咖啡之间存在微弱的正相关。曾饮酒与肾细胞癌呈强烈负相关，其中与葡萄酒的相关性最强。在男性中，人工甜味剂的使用与肾细胞癌呈正相关。这些发现增进了我们对这种人类罕见但日益重要的肿瘤性疾病病因的理解。
