van den Buuse M, de Jong W
Rudolf Magnus Institute for Pharmacology, University of Utrecht, Medical Faculty, The Netherlands.
Clin Exp Hypertens A. 1988;10(4):667-84. doi: 10.3109/10641968809033917.
The relation between the development of hypertension and changes in behaviour was investigated. Open-field activity of male and female Spontaneously Hypertensive Rats (SHR) and Wistar-Kyoto controls (WKY) was scored at 4, 6 or 10 weeks of age. SHR generally showed higher locomotor activity and exploratory rearing behaviour, but lower grooming activity and defecation. These changes were found for rearing (3-5 fold increase) and grooming scores at all ages, ambulation at 4 weeks and 10 weeks (ambulation-inner) and defecation at 6 and 10 weeks of age. Differences were generally more pronounced in female rats. SHR showed less habituation than WKY. Already at the age of 4 and 6 weeks blood pressure was increased in SHR compared with WKY (approximately 120 mm Hg vs. 100 mm Hg). Between 6 and 10 weeks of age blood pressure increased rapidly in SHR, leading to a marked difference at the latter age (about 40 mm Hg), in both male and female rats. These experiments show that already at a young age, when blood pressure differences with WKY are small, marked behavioural changes are present in SHR. The altered behaviour could play a role in the development of hypertension in SHR.
研究了高血压发展与行为变化之间的关系。对雄性和雌性自发性高血压大鼠（SHR）以及Wistar-Kyoto对照大鼠（WKY）在4周、6周或10周龄时的旷场活动进行评分。SHR通常表现出更高的运动活性和探究性竖毛行为，但理毛活动和排便较少。在所有年龄段，竖毛行为（增加3 - 5倍）和理毛得分、4周和10周龄时的行走（场内行走）以及6周和10周龄时的排便均出现这些变化。差异在雌性大鼠中通常更为明显。与WKY相比，SHR的习惯化程度较低。在4周和6周龄时，SHR的血压就已经高于WKY（约120 mmHg对100 mmHg）。在6至10周龄期间，SHR的血压迅速升高，导致在10周龄时雄性和雌性大鼠均出现明显差异（约40 mmHg）。这些实验表明，在与WKY血压差异较小的幼年时期，SHR就已经出现了明显的行为变化。行为改变可能在SHR高血压的发展中起作用。
