Nogueira Isabel Roldo, Coelho Julio Cezar Uili, Domingos Micheli Fortunato, Parolin Mônica Beatriz, Matias Jorge Eduardo Fouto, Freitas Alexandre Coutinho Teixeira de, Martins Eduardo Lopes, Costa Marco Aurélio Raeder da
Serviço de Transplante Hepático, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Serviço de Transplante Hepático, Hospital Nossa Senhora das Graças, Curitiba, PR, Brasil.
Arq Gastroenterol. 2021 Jan-Mar;58(1):10-16. doi: 10.1590/S0004-2803.202100000-04.
Receptors of living donor liver transplantation (LDLT) have higher rate of postoperative biliary and vascular complications that may reduce posttransplant quality of life (QOL) due to the need of invasive and repetitive treatments.
The purpose of our study is to assess the various aspects of QOL of receptors undergoing LDLT after 10 years of transplantation and to identify potential factors that might be associated with impaired QOL.
Data of all patients with more than 10 years of LDLT were retrospectively evaluated. Patients were interviewed through a quality of life questionnaire (SF-36).
From a total of 440 LT performed in 17 years (from September 1991 through December 2008), 78 patients underwent LDLT, of which 27 were alive and 25 answered completely the questionnaire. There were 17 (68%) men and 8 (32%) women, with a mean age of 38.6±18.5 years at the time of transplantation and mean follow up time of 15.1±1.9 years. The average MELD was 16.4±4.9 and the main indication for LT was hepatic cirrhosis caused by hepatitis B virus (32%). When compared to the general po-pulation, LDLT patients had lower mental health score (66.4 vs 74.5, P=0.0093) and higher vitality score (87.8 vs 71.9, P<0.001), functional aspects (94.6 vs 75.5, P=0.002), social aspects (93 vs 83.9, P=0.005), physical aspects (92 vs 77.5, P=0.006), and emotional aspects (97.33 vs 81.7, P<0.001). General health status (73.28 vs 70.2, P=0.074) and pain (78.72 vs 76.7, P=0.672) scores were similar in both groups.
It is concluded that the various aspects LDLT recipients' QOF are similar to those of the general population more than a decade after the transplant, except for the mental health domain which is lower.
活体供肝移植（LDLT）受体术后发生胆道和血管并发症的几率较高，由于需要进行侵入性和重复性治疗，这可能会降低移植后的生活质量（QOL）。
本研究旨在评估LDLT受体移植10年后生活质量的各个方面，并确定可能与生活质量受损相关的潜在因素。
对所有接受LDLT超过10年的患者数据进行回顾性评估。通过生活质量问卷（SF-36）对患者进行访谈。
在17年（从1991年9月至2008年12月）共进行的440例肝移植手术中，78例接受了LDLT，其中27例存活，25例完整回答了问卷。有17名（68%）男性和8名（32%）女性，移植时平均年龄为38.6±18.5岁，平均随访时间为15.1±1.9年。平均终末期肝病模型（MELD）评分为16.4±4.9，肝移植的主要指征是乙型肝炎病毒引起的肝硬化（32%）。与普通人群相比，LDLT患者的心理健康评分较低（66.4对74.5，P = 0.0093），活力评分较高（87.8对71.9，P < 0.001），功能方面（94.6对75.5，P = 0.002），社会方面（93对83.9，P = 0.005），身体方面（92对77.5，P = 0.006）和情感方面（97.33对81.7，P < 0.001）。两组的总体健康状况（73.28对70.2，P = 0.074）和疼痛（78.72对76.7，P = 0.672）评分相似。
得出的结论是，除心理健康领域较低外，LDLT受体移植十多年后的生活质量各个方面与普通人群相似。
