Doherty-Fuller E, Copeland K C
Department of Pediatrics, University of Vermont College of Medicine, Burlington 05405.
Clin Pediatr (Phila). 1988 Jul;27(7):330-2. doi: 10.1177/000992288802700704.
Increased sweat chloride concentrations have been reported in patients with nephrogenic (NDI) but not central diabetes insipidus (CDI). To determine whether false-positive sweat tests also occur in CDI, six subjects with CDI had plasma electrolytes, osmolatities, and sweat tests performed before and after water deprivation. All subjects were hyperosmolar after dehydration (287 +/- 2.0 and 296 +/- 3.2 mosm/kg, plasma osmolality before and after dehydration, respectively; p = 0.02). Sweat chloride concentrations before and after dehydration were not different, and no positive sweat tests were observed. Sweat chloride concentrations after dehydration did not correlate with the degree of dehydration as assessed by either plasma sodium or plasma osmolality. We conclude that increased concentrations of chloride in sweat are not typically found in dehydrated subjects with CDI, although they have been reported in subjects with the nephrogenic form.
据报道，肾性尿崩症（NDI）患者的汗液氯化物浓度会升高，但中枢性尿崩症（CDI）患者不会。为了确定CDI患者是否也会出现汗液检测假阳性，对6名CDI患者在禁水前后进行了血浆电解质、渗透压和汗液检测。所有受试者脱水后均为高渗状态（脱水前后血浆渗透压分别为287±2.0和296±3.2 mOsm/kg；p = 0.02）。脱水前后汗液氯化物浓度无差异，未观察到汗液检测阳性。脱水后汗液氯化物浓度与通过血浆钠或血浆渗透压评估的脱水程度无关。我们得出结论，尽管肾性尿崩症患者的汗液氯化物浓度有所升高，但脱水的CDI患者汗液中氯化物浓度通常不会升高。
