NLRP6 在宿主防御和肠道炎症中的作用。
NLRP6 in host defense and intestinal inflammation.
机构信息
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA; Department of Immunology, UT Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Division of Gastroenterology and Hepatology, School of Medicine at the Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.
出版信息
Cell Rep. 2021 Apr 27;35(4):109043. doi: 10.1016/j.celrep.2021.109043.
NLRP6 is a member of the NLR (nucleotide-oligomerization domain-like receptor) family of proteins that recognize pathogen-derived factors and damage-associated molecular patterns in the cytosol. The function of NLRP6 has been attributed to the maintenance of epithelial integrity and host defense against microbial infections. Under some physiological conditions, NLRP6 forms a complex with ASC and caspase-1 or caspase-11 to form an inflammasome complex cleaving pro-interleukin-1β (IL-1β) and IL-18 into their biologically active forms. Here, we summarize recent advances in the understanding of the mechanisms of activation of the NLRP6 inflammasome and discuss its relevance to human disease.
NLRP6 是 NLR（核苷酸寡聚化结构域样受体）家族蛋白的成员，可识别细胞溶质中的病原体衍生因子和损伤相关分子模式。NLRP6 的功能归因于维持上皮完整性和宿主防御微生物感染。在某些生理条件下，NLRP6 与 ASC 和 caspase-1 或 caspase-11 形成复合物，形成炎症小体复合物，将前白细胞介素-1β（IL-1β）和白细胞介素-18 切割成其生物活性形式。在这里，我们总结了对 NLRP6 炎症小体激活机制的理解的最新进展，并讨论了其与人类疾病的相关性。
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