Faculty of Medicine, Hebrew University of Jerusalem, Israel; The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah - Hebrew University Medical Center, Jerusalem, Israel.
Centre for Clinical Brain Sciences, MS Centre, University of Edinburgh, Edinburgh, United Kingdom.
J Neuroimmunol. 2021 Jul 15;356:577582. doi: 10.1016/j.jneuroim.2021.577582. Epub 2021 Apr 21.
We explored whether experimental autoimmune encephalomyelitis (EAE) in Biozzi mice recapitulates temporal dynamics of tissue injury, immune-pathogenesis and CNS compartmentalization occurring in progressive multiple sclerosis (MS). Chronic EAE exhibited relapsing and progressing disease, partial closure of BBB, reduced tissue inflammatory activity, and development of meningeal ectopic lymphoid tissue, directly opposing (potentially driving) spinal subpial demyelinated plaques. A T cell predominant disease during relapses transformed into a B cell predominant disease in late chronic EAE, with high serum anti-MOG reactivity. Thus, late chronic Biozzi EAE recapitulates essential features of progressive MS, and is suitable for developing disease modifying and regenerative therapies.
我们探索了生物佐兹（Biozzi）小鼠的实验性自身免疫性脑脊髓炎（EAE）是否重现了进行性多发性硬化症（MS）中发生的组织损伤、免疫发病机制和中枢神经系统分隔的时间动态。慢性 EAE 表现为复发和进行性疾病、部分血脑屏障（BBB）关闭、组织炎症活性降低以及脑膜异位淋巴组织的发展，直接对抗（潜在驱动）脊髓软脑膜脱髓鞘斑块。在复发期间以 T 细胞为主的疾病在慢性 EAE 晚期转变为以 B 细胞为主的疾病，伴有高血清抗髓鞘少突胶质细胞糖蛋白（MOG）反应性。因此，晚期慢性 Biozzi EAE 重现了进行性 MS 的基本特征，适合开发疾病修饰和再生疗法。
