Department of Pharmacy, College of Pharmacy, University of the Philippines Manila, Manila, Philippines.
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
Pharmacogenomics. 2021 Jun;22(8):465-472. doi: 10.2217/pgs-2020-0191. Epub 2021 Apr 29.
A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. The HLA-B75 serotype, or may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.
一项在菲律宾患者中进行的病例对照研究旨在确定 HLA 等位基因与卡马西平诱导的史蒂文斯-约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）之间的关联。对病历进行回顾性审查并收集数据。共招募了 10 例卡马西平诱导的 SJS/TEN 病例和 40 例耐受对照。从唾液样本中提取基因组 DNA 进行基因分型。进行了统计分析。HLA-B75 血清型（p=0.003；优势比[OR] = 13.8；95%置信区间[CI] = 2.5-76.8）、（p=0.041；OR=4.7；95%CI=1.1-20.8）和 （p=0.032；OR=6；95%CI=1.2-30.7）与卡马西平诱导的 SJS/TEN 显著相关。HLA-B75 血清型或 可能用于菲律宾人在开处方卡马西平之前进行药物遗传学筛查。
