作为菲律宾患者卡马西平诱导的史蒂文斯-约翰逊综合征/中毒性表皮坏死松解症的潜在生物标志物。
as a potential biomarker for carbamazepine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Filipino patients.
机构信息
Department of Pharmacy, College of Pharmacy, University of the Philippines Manila, Manila, Philippines.
Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
出版信息
Pharmacogenomics. 2021 Jun;22(8):465-472. doi: 10.2217/pgs-2020-0191. Epub 2021 Apr 29.
A case-control study was conducted in Filipino patients to determine the association between HLA alleles and carbamazepine-induced Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN). A retrospective review of medical records and data collection were performed. A total of 10 carbamazepine-induced SJS/TEN cases and 40 tolerant controls were recruited. Genomic DNA extracted from saliva samples was genotyped. Statistical analysis was done. The HLA-B75 serotype (p = 0.003; odds ratio [OR] = 13.8; 95% CI = 2.5-76.8), (p = 0.041; OR = 4.7; 95% CI = 1.1-20.8) and (p = 0.032; OR = 6; 95% CI = 1.2-30.7) were significantly associated with carbamazepine-induced SJS/TEN. The HLA-B75 serotype, or may be used for pharmacogenetic screening prior to prescribing carbamazepine in Filipinos.
一项在菲律宾患者中进行的病例对照研究旨在确定 HLA 等位基因与卡马西平诱导的史蒂文斯-约翰逊综合征（SJS）/中毒性表皮坏死松解症（TEN）之间的关联。对病历进行回顾性审查并收集数据。共招募了 10 例卡马西平诱导的 SJS/TEN 病例和 40 例耐受对照。从唾液样本中提取基因组 DNA 进行基因分型。进行了统计分析。HLA-B75 血清型（p=0.003；优势比[OR] = 13.8；95%置信区间[CI] = 2.5-76.8）、（p=0.041；OR=4.7；95%CI=1.1-20.8）和 （p=0.032；OR=6；95%CI=1.2-30.7）与卡马西平诱导的 SJS/TEN 显著相关。HLA-B75 血清型或 可能用于菲律宾人在开处方卡马西平之前进行药物遗传学筛查。
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