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非囊性纤维化支气管扩张症中铜绿假单胞菌定植的危险因素及其临床意义。

Risk factors for Pseudomonas aeruginosa colonization in non-cystic fibrosis bronchiectasis and clinical implications.

机构信息

Department of Medicine, Queen Mary Hospital, University of Hong Kong, 102 Pokfulam Road, Pokfulam, Hong Kong Special Administrative Region, China.

出版信息

Respir Res. 2021 Apr 28;22(1):132. doi: 10.1186/s12931-021-01729-5.

DOI:10.1186/s12931-021-01729-5
PMID:33910573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8080398/
Abstract

BACKGROUND

Pseudomonas aeruginosa is one of the commonest bacteria colonizing the airway in patients with non-cystic fibrosis bronchiectasis. Pseudomonas aeruginosa colonization is associated with poor outcomes in patients with bronchiectasis, including rapid decline in lung function, exacerbation frequency and hospitalization.

METHODS

A cross-sectional study in Queen Mary Hospital, Hong Kong that included 350 Chinese patients with non-cystic fibrosis bronchiectasis to investigate the risk factors for Pseudomonas aeruginosa colonization and clinical implications on disease outcomes.

DISCUSSIONS

Pseudomonas aeruginosa colonization was more commonly found in patients with longer duration of bronchiectasis and those on proton pump inhibitors (PPIs) with adjusted ORs of 1.066 (95% CI = 1.036-1.096, p < 0.001) and 2.815 (95% CI = 1.307-6.064, p = 0.008) respectively. Patients with Pseudomonas aeruginosa colonization have more extensive lung involvement and higher risks of exacerbation requiring hospitalization with adjusted ORs of 2.445 (95% CI = 1.283-4.657, p = 0.007) and 2.745 (95% CI = 1.012-7.449, p = 0.047) respectively. Pseudomonas aeruginosa colonization is more common among patients with longer duration of bronchiectasis and those on PPI. Pseudomonas aeruginosa colonization is associated with more extensive lung involvement and higher risks of exacerbation requiring hospitalization.

摘要

背景

铜绿假单胞菌是引起非囊性纤维化支气管扩张症患者气道定植的最常见细菌之一。铜绿假单胞菌定植与支气管扩张症患者的不良结局相关，包括肺功能下降迅速、加重频率增加和住院率增加。

方法

在香港玛丽医院进行的一项横断面研究，纳入了 350 名非囊性纤维化支气管扩张症的中国患者，旨在探讨铜绿假单胞菌定植的危险因素及其对疾病结局的临床意义。

讨论

铜绿假单胞菌定植在支气管扩张症病程较长和使用质子泵抑制剂（PPIs）的患者中更为常见，调整后的比值比（OR）分别为 1.066（95%置信区间[CI]：1.036-1.096，p<0.001）和 2.815（95% CI：1.307-6.064，p=0.008）。铜绿假单胞菌定植的患者肺部受累更广泛，需要住院治疗的加重风险更高，调整后的 OR 分别为 2.445（95% CI：1.283-4.657，p=0.007）和 2.745（95% CI：1.012-7.449，p=0.047）。

结论

铜绿假单胞菌定植在支气管扩张症病程较长和使用 PPI 的患者中更为常见。铜绿假单胞菌定植与肺部受累更广泛以及需要住院治疗的加重风险增加相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0b/8080398/825ecf6b02a9/12931_2021_1729_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0b/8080398/825ecf6b02a9/12931_2021_1729_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bc0b/8080398/825ecf6b02a9/12931_2021_1729_Fig1_HTML.jpg

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