低估大体肿瘤型硬纤维瘤的放射治疗价值：需要进行绝对体积评估。
Undervaluation of Radiotherapy for Gross Desmoid Tumors: The Need for Absolute Volume Assessment.
机构信息
Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea;
出版信息
In Vivo. 2021 May-Jun;35(3):1777-1784. doi: 10.21873/invivo.12437.
BACKGROUND/AIM: To compare absolute volume (AV) assessment according to Response Evaluation Criteria in Solid Tumors (RECIST) for the response evaluation of desmoid tumors (DTs) treated with radiotherapy.
PATIENTS AND METHODS
Eighteen patients with DTs ≥3 cm in size were included.
RESULTS
The median follow-up duration was 78.0 months. Five patients achieved a complete response according to RECIST, seven reached a partial response (PR), and one eventually exhibited progression. The overall response rate was 61%, the median time to PR was 8.0 months. Six patients achieved stable disease, although three developed progressions. Of the six patients with a PR, the median change in maximum diameter was -46%, and the median change in maximum volume was -84%. Three patients could have been diagnosed with progression at least 6 months earlier if the AV increment was considered.
CONCLUSION
An AV assessment is essential for an accurate response assessment of DTs and radiotherapy seems feasible as a first-line treatment for DTs.
背景/目的：比较接受放疗的硬纤维瘤（DT）患者的实体瘤反应评估标准（RECIST）的绝对体积（AV）评估，以评估其反应。
患者和方法
共纳入 18 名大小≥3 cm 的 DT 患者。
结果
中位随访时间为 78.0 个月。5 名患者根据 RECIST 达到完全缓解，7 名达到部分缓解（PR），1 名最终出现进展。总缓解率为 61%，PR 的中位时间为 8.0 个月。6 名患者疾病稳定，尽管其中 3 名出现进展。在 6 名 PR 患者中，最大直径的中位变化为-46%，最大体积的中位变化为-84%。如果考虑 AV 增量，则有 3 名患者至少可以提前 6 个月诊断为进展。
结论
AV 评估对于 DT 的准确反应评估至关重要，放疗似乎是 DT 的一线治疗方法。
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