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通过血管化水凝胶递送卵巢球体来实现激素的自分泌，以挽救卵巢功能障碍。

Hormone autocrination by vascularized hydrogel delivery of ovary spheroids to rescue ovarian dysfunctions.

机构信息

Department of Medical Engineering, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

Institute of Women's Life Medical Science, Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

出版信息

Sci Adv. 2021 Apr 28;7(18). doi: 10.1126/sciadv.abe8873. Print 2021 Apr.

DOI:10.1126/sciadv.abe8873
PMID:33910892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8081364/
Abstract

The regeneration potential of implantable organ model hydrogels is applied to treat a loss of ovarian endocrine function in women experiencing menopause and/or cancer therapy. A rat ovariectomy model is used to harvest autologous ovary cells while subsequently producing a layer-by-layer form of follicle spheroids. Implantation of a microchannel network hydrogel with cell spheroids [vascularized hydrogel with ovarian spheroids (VHOS)] into an ischemic hindlimb of ovariectomized rats significantly aids the recovery of endocrine function with hormone release, leading to full endometrium regeneration. The VHOS implantation effectively suppresses the side effects observed with synthetic hormone treatment (i.e., tissue overgrowth, hyperplasia, cancer progression, deep vein thrombosis) to the normal levels, while effectively preventing the representative aftereffects of menopause (i.e., gaining fatty weight, inducing osteoporosis). These results highlight the unprecedented therapeutic potential of an implantable VHOS against menopause and suggest that it may be used as an alternative approach to standard hormone therapy.

摘要

植入型器官模型水凝胶的再生潜力被应用于治疗女性更年期和/或癌症治疗导致的卵巢内分泌功能丧失。利用大鼠卵巢切除术模型来收获自体卵巢细胞，然后形成层状的卵泡球体。将微通道网络水凝胶与细胞球体（血管化卵巢球体水凝胶（VHOS））一起植入去卵巢大鼠的缺血后肢，可显著促进激素释放的内分泌功能恢复，导致子宫内膜完全再生。VHOS 的植入有效地将合成激素治疗观察到的副作用（即组织过度生长、增生、癌症进展、深静脉血栓形成）抑制到正常水平，同时有效地预防了更年期的代表性后遗症（即增加体脂、骨质疏松症）。这些结果突出了植入型 VHOS 治疗更年期的前所未有的治疗潜力，并表明它可能被用作替代标准激素治疗的方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/0363d72909bf/abe8873-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/94a368021d16/abe8873-F1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/99d46953d053/abe8873-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/941e741b0872/abe8873-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/b2e4b1ae939d/abe8873-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/0363d72909bf/abe8873-F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/94a368021d16/abe8873-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/11c1449f7ff4/abe8873-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/99d46953d053/abe8873-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/941e741b0872/abe8873-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/b2e4b1ae939d/abe8873-F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/220b/8081364/0363d72909bf/abe8873-F6.jpg

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