Yang Ying, Chen Xiang, Ma Changyan
Department of Medical Genetics, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, Jiangsu 211166, China.
Department of General Surgery, the Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu 214200, China.
J Biomed Res. 2020 Aug 28;35(3):189-196. doi: 10.7555/JBR.34.20200082.
Triple-negative breast cancer (TNBC) has a poor prognosis and typically earlier onset of metastasis in comparison with other breast cancer subtypes. It has been reported that insulin receptor (INSR) is downregulated in TNBC, however, its clinical significance and functions in TNBC remain to be elucidated. In this study, we found that INSR expression was significantly downregulated in TNBC, and overexpression of INSR suppressed cell migration and invasion in TNBC. In addition, the survival rate of breast cancer patients with low INSR expression was lower than that of patients with high INSR expression. INSR expression was significantly correlated with lymph node metastasis, clinical tumor stages, ER status, PR status, and the proliferation index Ki-67 expression. In summary, our study suggests that INSR may serve as a biomarker for breast cancer prognosis and it may be a potential target for TNBC treatment.
三阴性乳腺癌（TNBC）预后较差，与其他乳腺癌亚型相比，通常转移发生得更早。据报道，胰岛素受体（INSR）在TNBC中表达下调，然而，其在TNBC中的临床意义和功能仍有待阐明。在本研究中，我们发现INSR表达在TNBC中显著下调，并且INSR的过表达抑制了TNBC中的细胞迁移和侵袭。此外，INSR低表达的乳腺癌患者的生存率低于INSR高表达的患者。INSR表达与淋巴结转移、临床肿瘤分期、雌激素受体（ER）状态、孕激素受体（PR）状态以及增殖指数Ki-67表达显著相关。总之，我们的研究表明，INSR可能作为乳腺癌预后的生物标志物，并且它可能是TNBC治疗的潜在靶点。
