[Effect of modifiers of microsomal enzymes on the enzymatic denitrosation of dialkyl-N-nitrosamines].
作者信息
Arshinov V Iu, Shuliakovskaia T S
出版信息
Eksp Onkol. 1988;10(2):20-2.
PMID:3391120
Abstract
The antioxidant butyl-hydroxytoluene has been shown to increase denitrosation of some dialkyl-N-nitrosamines by the liver microsomes of different lines of rats and to protect against diethyl-N-nitrosamine toxicity. 3-Methylcholanthrene, while decreasing denitrosation of diethyl-N-nitrosamine, increased its toxic effect. This data suggested that enzymatic denitrosation is an effective pathway for the inactivation of dialkyl-N-nitrosamines.
摘要
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