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贝克尔痣中的神经肽谱与神经支配增加

Neuropeptides Profile and Increased Innervation in Becker's Nevus.

作者信息

Kim Ji Seok, Park Myeong Jin, Kang Hye Young, Hong Seung Phil, Park Byung Cheol, Kim Myung Hwa

机构信息

Department of Dermatology, Dankook University College of Medicine, Cheonan, Korea.

出版信息

Ann Dermatol. 2019 Apr;31(2):154-163. doi: 10.5021/ad.2019.31.2.154. Epub 2019 Feb 28.

DOI:10.5021/ad.2019.31.2.154
PMID:33911564
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7992669/
Abstract

BACKGROUND

Melanocytes are derived from neural crest, and various pigmentary disorders may accompany abnormalities in nerve system or develop following dermatome, suggesting that melanocyte and pigmentation may be closely related to neural factors. There are reports of Becker's nevus (BN) showing linear and segmental configuration, suggesting the association of BN with nerve system. However, there are no studies regarding the expression of neuropeptides in BN.

OBJECTIVE

We investigated the expression of neuropeptides and innervation in BN.

METHODS

Polymerase chain reaction (PCR) array of 84 genes related to neuronal process was done. Among the genes with 10-fold or more increase in lesional, real-time PCR was performed for neuropeptide Y (NPY), galanin, neurotensin (NTS) and their receptors skin compared to normal skin. IHC stain was done to look for the expression of NPY, galanin, NTS and their receptors and the distribution of protein gene products (PGP) 9.5 immunoreactive nerve fibers.

RESULTS

PCR array revealed that 16 out of 84 genes related to neuronal process were increased by 10-fold or more in lesional skin. In real-time PCR of NPY, galanin, NTS and their receptors, statistically significant increase of NPY1R (<0.05) and marginally significant increase of NPY2R, GAL2R, and NTS2R (<0.1) was verified in lesional skin. In immunohistochemistry, NPY, NPY1R NPY2R, and NTS2R were highly expressed in lesional skin and increased PGP 9.5 immunoreactive linear nerve fibers were found in the epidermis of BN.

CONCLUSION

NPY, galanin, NTS and their receptors and increased innervation may play a role in the pathogenesis of BN.

摘要

背景

黑素细胞起源于神经嵴，各种色素沉着紊乱可能伴有神经系统异常或沿皮节发展，这表明黑素细胞和色素沉着可能与神经因素密切相关。有报道称贝克尔痣（BN）呈线状和节段性分布，提示BN与神经系统有关。然而，关于BN中神经肽表达的研究尚无报道。

目的

我们研究了BN中神经肽的表达及神经支配情况。

方法

对84个与神经元过程相关的基因进行聚合酶链反应（PCR）芯片检测。在病变部位基因表达增加10倍或更多的基因中，与正常皮肤相比，对神经肽Y（NPY）、甘丙肽、神经降压素（NTS）及其受体进行实时PCR检测。进行免疫组化染色以观察NPY、甘丙肽、NTS及其受体的表达以及蛋白基因产物（PGP）9.5免疫反应性神经纤维的分布。

结果

PCR芯片显示，84个与神经元过程相关的基因中有16个在病变皮肤中表达增加10倍或更多。在对NPY、甘丙肽、NTS及其受体的实时PCR检测中，病变皮肤中NPY1R有统计学意义的增加（<0.05），NPY2R、GAL2R和NTS2R有边缘性显著增加（<0.1）。免疫组化显示，NPY、NPY1R、NPY2R和NTS2R在病变皮肤中高表达，且在BN表皮中发现PGP 9.5免疫反应性线性神经纤维增加。

结论

NPY、甘丙肽、NTS及其受体以及神经支配增加可能在BN的发病机制中起作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/88257e47d3e0/ad-31-154-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/cf8dfe558110/ad-31-154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/f7e4ee15d0d6/ad-31-154-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/3f4bf95737ed/ad-31-154-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/3cfe3379d81e/ad-31-154-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/5409ed9ae2a9/ad-31-154-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/6aa4e7aa9cf6/ad-31-154-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/88257e47d3e0/ad-31-154-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/cf8dfe558110/ad-31-154-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/f7e4ee15d0d6/ad-31-154-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/3f4bf95737ed/ad-31-154-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/3cfe3379d81e/ad-31-154-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/5409ed9ae2a9/ad-31-154-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/6aa4e7aa9cf6/ad-31-154-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbef/7992669/88257e47d3e0/ad-31-154-g007.jpg

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Clinicopathological Features and Immunohistochemical Alterations of Keratinocyte Proliferation, Melanocyte Density, Smooth Muscle Hyperplasia and Nerve Fiber Distribution in Becker's Nevus.贝克尔痣中角质形成细胞增殖、黑素细胞密度、平滑肌增生及神经纤维分布的临床病理特征与免疫组化改变
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