Choi Hoon, Kim Choong Jae, Kim Min Sung, Shin Bong Seok, Na Chan Ho
Department of Dermatology, School of Medicine, Chosun University, Gwangju, Korea.
Ann Dermatol. 2019 Oct;31(5):571-575. doi: 10.5021/ad.2019.31.5.571. Epub 2019 Aug 30.
is a dematiaceous fungus capable of causing soft tissue infections known as phaeohyphomycosis, mostly in immunocompromised individuals. These infections arise from the traumatic inoculation of fungal materials into the subcutis, and can spread to adjacent subcutaneous tissues or via the lymphatics in a sporotrichoid manner. A 76-year-old man presented with diffuse erythematous plaques and swelling on both forearms and dorsal hands, and rhinalgia. He had been undergoing treatment for hypertension, angina pectoris, and diabetes. Histopathologic examinations of the skin, painful nasal septum, and molecular identification using internal transcribed spacer regions confirmed a diagnosis of subcutaneous and intranasal phaeohyphomycosis caused by . The patient was treated with oral itraconazole for over 5 months, and no recurrence was observed until the time of writing this manuscript. We report a rare case of subcutaneous and intranasal phaeohyphomycosis caused by and propose that confirmation of the causative strains is necessary, as it could affect the prognosis and treatment of the disease.
是一种暗色真菌，能够引起称为暗色丝孢霉病的软组织感染，主要发生在免疫功能低下的个体中。这些感染源于真菌物质经创伤接种到皮下组织，可呈孢子丝菌病样方式扩散至邻近的皮下组织或通过淋巴管扩散。一名76岁男性患者，双侧前臂和手背出现弥漫性红斑斑块及肿胀，伴有鼻痛。他一直在接受高血压、心绞痛和糖尿病的治疗。对皮肤、疼痛的鼻中隔进行组织病理学检查，并使用内转录间隔区进行分子鉴定，确诊为由……引起的皮下和鼻内暗色丝孢霉病。该患者接受口服伊曲康唑治疗超过5个月，直至撰写本文时未观察到复发。我们报告了一例由……引起的罕见的皮下和鼻内暗色丝孢霉病病例，并提出确认致病菌株是必要的，因为这可能影响疾病的预后和治疗。
