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E-钙黏蛋白在胰腺癌患者中的预后及临床病理意义：一项Meta分析

Prognostic and Clinicopathological Significance of E-Cadherin in Pancreatic Cancer Patients: A Meta-Analysis.

作者信息

Wang Pengbo, Zhu Zengkuan

机构信息

Radiotherapy Department I, Yantaishan Hospital, Yantai, China.

Department of Oncology, Shengli Oilfield Central Hospital, Dongying, China.

出版信息

Front Oncol. 2021 Apr 12;11:627116. doi: 10.3389/fonc.2021.627116. eCollection 2021.

DOI:10.3389/fonc.2021.627116
PMID:33912451
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8074677/
Abstract

BACKGROUND

Several recent studies have investigated the prognostic and clinicopathological significance of epithelial cadherin (E-cadherin) in pancreatic cancer; however, conclusions from these studies remain inconsistent. Therefore, we performed a meta-analysis to evaluate the effects of E-cadherin expression on the prognosis and clinicopathological characteristics of pancreatic cancer.

METHODS

Embase, PubMed, and Web of Science were searched to identify articles associated with E-cadherin and pancreatic cancer. Hazard ratios (HRs) and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized. All eligible studies were searched until May 20, 2020. Heterogeneity among studies was assessed using the Chi-square test and I statistic.

RESULTS

Overall, 25 studies were identified, of which 12 reports with 1,032 cases concerned the prognosis of pancreatic cancer, and 22 involved the risk and clinical characteristics of pancreatic cancer. The overall results revealed that E-cadherin expression was significantly related to overall survival, gender, tumor grade, lymph node metastasis, tumor differentiation, and risk of pancreatic cancer. In the subgroup analysis, no significant heterogeneity or publication bias was observed.

CONCLUSIONS

E-cadherin expression is strongly associated with the risk, clinical features, and prognosis of pancreatic cancer, suggesting that E-cadherin may be an effective biomarker for the clinical assessments and predicting prognosis of pancreatic cancer.

摘要

背景

最近的几项研究探讨了上皮钙黏蛋白（E-cadherin）在胰腺癌中的预后及临床病理意义；然而，这些研究得出的结论仍不一致。因此，我们进行了一项荟萃分析，以评估E-cadherin表达对胰腺癌预后及临床病理特征的影响。

方法

检索Embase、PubMed和Web of Science，以识别与E-cadherin和胰腺癌相关的文章。计算并汇总风险比（HRs）和比值比（ORs）及其相应的置信区间（CIs）。检索所有符合条件的研究至2020年5月20日。使用卡方检验和I统计量评估研究间的异质性。

结果

总体而言，共识别出25项研究，其中12篇报告（涉及1032例病例）关注胰腺癌的预后，22项研究涉及胰腺癌的风险及临床特征。总体结果显示，E-cadherin表达与总生存期、性别、肿瘤分级、淋巴结转移、肿瘤分化及胰腺癌风险显著相关。在亚组分析中，未观察到显著的异质性或发表偏倚。

结论

E-cadherin表达与胰腺癌的风险、临床特征及预后密切相关，表明E-cadherin可能是用于胰腺癌临床评估和预测预后的有效生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/6d93cadd2984/fonc-11-627116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/6e9ad8ac86c2/fonc-11-627116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/00c571232a07/fonc-11-627116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/6d93cadd2984/fonc-11-627116-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/6e9ad8ac86c2/fonc-11-627116-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/00c571232a07/fonc-11-627116-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e262/8074677/6d93cadd2984/fonc-11-627116-g003.jpg

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