1月龄牛胎儿的神经垂体激素：哺乳动物发育过程中血管催产素的缺失

Neurohypophysial hormones of the 1-month-old bovine fetus: absence of vasotocin during mammal development.

作者信息

Rouille Y, Levy B, Chauvet M T, Chauvet J, Acher R

机构信息

Laboratory of Biological Chemistry, University of Paris VI, France.

出版信息

FEBS Lett. 1988 Jul 18;234(2):345-8. doi: 10.1016/0014-5793(88)80113-3.

DOI:10.1016/0014-5793(88)80113-3

PMID:3391278

Abstract

The neurohypophysial hormones of the 1-month-old bovine fetus have been identified by their positions in ion-exchange chromatography and their retention times in high-pressure reverse-phase partition chromatography. Arginine vasopressin and oxytocin have been recognized. The molar ratio vasopressin/oxytocin in neurohypophysis is about 6 in the 1-month-old fetus compared with 4 in the 3-month-old fetus, 2.7 in the 7-month-old fetus and 1 in the adult. Vasotocin is virtually absent even in the early fetus (less than 0.1% of arginine vasopressin). The occurrence of a vasotocin gene expressed in the fetus but silent in the adult appears unlikely.

摘要

1月龄牛胎儿的神经垂体激素已通过其在离子交换色谱中的位置以及在高压反相分配色谱中的保留时间得以鉴定。已识别出精氨酸加压素和催产素。1月龄胎儿神经垂体中加压素/催产素的摩尔比约为6，而3月龄胎儿为4，7月龄胎儿为2.7，成人为1。即使在早期胎儿中（不到精氨酸加压素的0.1%），加压素也几乎不存在。胎儿中表达但在成体中沉默的加压素基因的出现似乎不太可能。