Akkoca Özlem, Kargın Kaytez Selda, Yumuşak Nihat, Bilgen Akif Sinan, Kavuzlu Ali, Öcal Ramazan, Çelik Hatice, Arslan Necmi
Department of Otorhinolaryngology, University of Health Sciences Ankara Training and Research Hospital, Ankara, Turkey.
Department of Pathology, Harran University Faculty of Veterinary Medicine, Şanlıurfa, Turkey.
Turk Arch Otorhinolaryngol. 2021 Mar;59(1):26-32. doi: 10.4274/tao.2020.5827. Epub 2021 Mar 26.
The aim of this study was to investigate the preventative effect of oral curcumin (CMN) on myringosclerosis (MS) in an experimental rat model.
The study included 21 female Wistar albino rats randomly separated into three groups. Group 1 was given no treatment (control group). In Group 2 and Group 3, the tympanic membrane (TM) was perforated using a sterile ear pick. The rats in Group 3 were administered oral CMN 200 mg/kg/day. All rats were sacrificed after 16 days. Otomicroscopic and histopathologic examinations were performed on the tympanic membranes.
Histopathologic examinations revealed that there were statistically significant differences between Group 2 and Group 3 in terms of MS degrees (p<0.001) and mean thicknesses of TMs (p<0.001), but there were no differences between Group 1 and Group 3. In respect of MS detected by otomicroscopy, a statistically significant difference was determined between Groups 1 and 2 (p<0.001) and between Groups 2 and 3 (p<0.01), but there was no significant difference between Group 1 and Group 3 (p=0.575).
Orally administered CMN can prevent myringosclerosis formation in experimentally induced myringotomies.
本研究旨在探讨口服姜黄素（CMN）对实验性大鼠鼓膜硬化（MS）的预防作用。
本研究纳入21只雌性Wistar白化大鼠，随机分为三组。第1组不进行治疗（对照组）。第2组和第3组使用无菌耳镊在鼓膜（TM）上穿孔。第3组大鼠口服CMN，剂量为200 mg/kg/天。16天后处死所有大鼠，对鼓膜进行耳显微镜检查和组织病理学检查。
组织病理学检查显示，第2组和第3组在MS程度（p<0.001）和TM平均厚度（p<0.001）方面存在统计学显著差异，但第1组和第3组之间无差异。在耳显微镜检查检测到的MS方面，第1组和第2组之间（p<0.001）以及第2组和第3组之间（p<0.01）存在统计学显著差异，但第1组和第3组之间无显著差异（p=0.575）。
口服CMN可预防实验性鼓膜切开术中鼓膜硬化形成。
