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大鼠诱导性鼓膜硬化的耳显微镜和组织学研究：一种实验模型的批判性研究

Otomicroscopic and histologic findings of induced myringosclerosis in rats: a critical study of an experimental model.

作者信息

Santos Patrícia F, Leal Mariana C, Peixoto Cristina, Caldas Neto Silvio, Rosas Silvania Tavares Paz

机构信息

Center of Health Sciences, Federal University of Pernambuco.

出版信息

Braz J Otorhinolaryngol. 2005 Sep-Oct;71(5):668-74. doi: 10.1016/s1808-8694(15)31272-6. Epub 2006 Mar 31.

DOI:10.1016/s1808-8694(15)31272-6
PMID:16612530
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9442119/
Abstract

UNLABELLED

Myringosclerosis is characterized by hyaline changes of the lamina propria of the tympanic membrane. Experimental studies have used otomicroscopy or histology to evaluate myringosclerosis in animals, but they do not correlate precisely these two methods.

AIM

The present study evaluates the accuracy of otomicroscopy in the diagnosis of myringosclerosis in rats.

STUDY DESIGN

Experimental.

MATERIAL AND METHOD

Myringosclerosis was induced by transtympanic inoculation of Streptococcus pneumoniae in 25 Wistar rats, which were examined weekly through otomicroscopy and sacrificed after eight weeks for histologic study of their tympanic membranes.

RESULTS

From the comparison of the otomicroscopic data in relation to the histologic findings, we could observe sensibility of 80% and specificity of 75% for the otomicroscopy.

CONCLUSION

Considering the results in this study, otomicroscopy did not represent a good method to evaluate myringosclerosis in this experimental model.

摘要

未标注

鼓膜硬化症的特征是鼓膜固有层的透明样改变。实验研究已使用耳显微镜检查或组织学来评估动物的鼓膜硬化症，但它们并未精确关联这两种方法。

目的

本研究评估耳显微镜检查诊断大鼠鼓膜硬化症的准确性。

研究设计

实验性研究。

材料与方法

通过经鼓膜接种肺炎链球菌在25只Wistar大鼠中诱发鼓膜硬化症，每周通过耳显微镜检查对其进行检查，并在八周后处死以对其鼓膜进行组织学研究。

结果

通过将耳显微镜检查数据与组织学结果进行比较，我们观察到耳显微镜检查的敏感度为80%，特异度为75%。

结论

考虑到本研究的结果，在该实验模型中，耳显微镜检查并非评估鼓膜硬化症的好方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/2118f047dca0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/5d5267d5f53b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/cc413ab83950/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/edaef4d4d7ad/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/c15238cc5f60/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/f2818dfdeb43/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/2118f047dca0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/5d5267d5f53b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/cc413ab83950/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/edaef4d4d7ad/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/c15238cc5f60/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/f2818dfdeb43/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86dd/9442119/2118f047dca0/gr6.jpg

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