Siemiatycki J, Colle E, Campbell S, Dewar R, Aubert D, Belmonte M M
Center of Research on Epidemiology and Preventive Medicine, Institut Armand-Frappier, Laval-des-Rapides, Quebec, Canada.
Diabetes. 1988 Aug;37(8):1096-102. doi: 10.2337/diab.37.8.1096.
We examined the incidence of insulin-dependent diabetes mellitus (IDDM) among children aged 0-14 yr in Montreal by social class and by ethnic group from 1971 to 1985. There was a slightly higher risk in wealthier as opposed to poorer classes. This income gradient was more marked in younger than in older children. Children of French extraction had about two-thirds the risk of IDDM of children of other origins, mainly British and other European. This mimics the patterns of risk in Europe, where France is reported to have lower rates than does Britain and Scandinavia. The absolute levels of risks among French Canadian and Jewish Canadian children were about double those reported from France and Israel, respectively. These various results are compatible with the hypothesis that both genetic and environmental factors influence IDDM risk.
我们研究了1971年至1985年间,蒙特利尔0至14岁儿童中胰岛素依赖型糖尿病(IDDM)按社会阶层和种族划分的发病率。较富裕阶层的患病风险略高于较贫困阶层。这种收入梯度在年幼儿童中比在年长儿童中更为明显。法裔儿童患IDDM的风险约为其他血统儿童(主要是英裔和其他欧洲裔)的三分之二。这与欧洲的风险模式相似,据报道法国的发病率低于英国和斯堪的纳维亚半岛。法裔加拿大儿童和犹太裔加拿大儿童的绝对风险水平分别约为法国和以色列报告水平的两倍。这些不同的结果与遗传和环境因素均影响IDDM风险这一假设相符。