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短篇通讯:印度西部 HIV 感染者中的 2019 冠状病毒病:一项观察性队列研究。

Short Communication: Coronavirus Disease 19 Among People Living with HIV in Western India: An Observational Cohort Study.

机构信息

Institute of Infectious Diseases, Pune, India.

Department of HIV Medicine and Infectious Diseases, Poona Hospital and Research Center, Pune, India.

出版信息

AIDS Res Hum Retroviruses. 2021 Aug;37(8):620-623. doi: 10.1089/AID.2021.0004. Epub 2021 May 31.

Abstract

A retrospective cohort study was conducted to assess clinical characteristics and outcomes of coronavirus disease-19 (COVID-19) among people living with HIV (PLHIV) in western India. Out of 86 PLHIV with COVID-19 illness, 19.7% had severe/critical illness and 6 (6.9%) individuals died. Median (interquartile range) age was 51 (47-56) years and 77.6% were male. Eighty-five PLHIV were on antiretroviral treatment with 98% having a viral load <200 copies/mL. Hypertension (HTN) (38.3%) and diabetes mellitus (17.4%) were commonest comorbidities. Fifty-eight percent PLHIV were hospitalized while 6.9% individuals needed intensive care. Presence of medical comorbidity was significantly associated with severe/critical COVID-19, whereas HTN was significantly associated with mortality. Recovery from COVID-19 was documented in 93% PLHIV. In conclusion, PLHIV in western India have similar COVID-19 clinical outcomes as compared with those reported historically among general population. Presence of medical comorbidities rather than HIV-related disease characteristics is associated with severe COVID-19 illness.

摘要

一项回顾性队列研究评估了印度西部 HIV 感染者(PLHIV)中 COVID-19 的临床特征和结局。在 86 名患有 COVID-19 的 PLHIV 中,19.7%患有严重/危重症疾病,6 人(6.9%)死亡。中位(四分位间距)年龄为 51(47-56)岁,77.6%为男性。85 名 PLHIV 正在接受抗逆转录病毒治疗,98%的病毒载量<200 拷贝/ml。高血压(HTN)(38.3%)和糖尿病(17.4%)是最常见的合并症。58%的 PLHIV 住院,6.9%的患者需要重症监护。93%的 PLHIV 从 COVID-19 中康复。结论:与历史上一般人群报告的 COVID-19 临床结局相比,印度西部的 PLHIV 具有相似的结局。存在合并症而非 HIV 相关疾病特征与严重 COVID-19 相关。

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