Institute of Infectious Diseases, Pune, India.
Department of HIV Medicine and Infectious Diseases, Poona Hospital and Research Center, Pune, India.
AIDS Res Hum Retroviruses. 2021 Aug;37(8):620-623. doi: 10.1089/AID.2021.0004. Epub 2021 May 31.
A retrospective cohort study was conducted to assess clinical characteristics and outcomes of coronavirus disease-19 (COVID-19) among people living with HIV (PLHIV) in western India. Out of 86 PLHIV with COVID-19 illness, 19.7% had severe/critical illness and 6 (6.9%) individuals died. Median (interquartile range) age was 51 (47-56) years and 77.6% were male. Eighty-five PLHIV were on antiretroviral treatment with 98% having a viral load <200 copies/mL. Hypertension (HTN) (38.3%) and diabetes mellitus (17.4%) were commonest comorbidities. Fifty-eight percent PLHIV were hospitalized while 6.9% individuals needed intensive care. Presence of medical comorbidity was significantly associated with severe/critical COVID-19, whereas HTN was significantly associated with mortality. Recovery from COVID-19 was documented in 93% PLHIV. In conclusion, PLHIV in western India have similar COVID-19 clinical outcomes as compared with those reported historically among general population. Presence of medical comorbidities rather than HIV-related disease characteristics is associated with severe COVID-19 illness.
一项回顾性队列研究评估了印度西部 HIV 感染者(PLHIV)中 COVID-19 的临床特征和结局。在 86 名患有 COVID-19 的 PLHIV 中,19.7%患有严重/危重症疾病,6 人(6.9%)死亡。中位(四分位间距)年龄为 51(47-56)岁,77.6%为男性。85 名 PLHIV 正在接受抗逆转录病毒治疗,98%的病毒载量<200 拷贝/ml。高血压(HTN)(38.3%)和糖尿病(17.4%)是最常见的合并症。58%的 PLHIV 住院,6.9%的患者需要重症监护。93%的 PLHIV 从 COVID-19 中康复。结论:与历史上一般人群报告的 COVID-19 临床结局相比,印度西部的 PLHIV 具有相似的结局。存在合并症而非 HIV 相关疾病特征与严重 COVID-19 相关。