Pd-Catalyzed double carbopalladation/-insertion cascade reactions toward medium-size sulfoximine heterocycles.
作者信息
Dai Longji, Yuan Jianjun, Wu Cui, Chen Zhiyuan
机构信息
Key Laboratory of Functional Small Organic Molecules, Ministry of Education and Jiangxi Key Laboratory of Green Chemistry, College of Chemistry & Chemical Engineering, Jiangxi Normal University, 99 Ziyang Road, Nanchang, Jiangxi 330022, P. R. China.
出版信息
Chem Commun (Camb). 2021 Apr 29;57(35):4271-4274. doi: 10.1039/d1cc00846c.
With the assistance of Ac in sulfoximine as a protecting group (PG) and MeOH as a de-PG agent, Pd-catalyzed multicomponent reactions were developed to access indene-fused medium-size sulfoximine heterocycles. The reactions proceeded smoothly under exceptionally mild conditions to produce polyheterocyclic sulfoximines with regiospecificity and good functional group tolerance. A double carbopalladation/syn-insertion of triple bond sequences was proposed tothis transformation.
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