Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
Kessler Foundation, West Orange, NJ, USA.
Acta Neurol Scand. 2021 Sep;144(3):260-265. doi: 10.1111/ane.13441. Epub 2021 Apr 29.
Aerobic reserve capacity reflects the available energy for performing everyday life tasks, and it has been studied in older adult populations. This preliminary study examined proof of concept and measurement of aerobic reserve capacity in multiple sclerosis (MS).
MATERIALS & METHODS: Twenty-one fully ambulatory people with MS performed a maximal, cardiopulmonary exercise test (CPET). We calculated aerobic reserve capacity based on the difference between peak aerobic power (VO ) and first stage oxygen consumption (VO ). Participants completed assessments for disability (Expanded Disability Status Scale, EDSS), cognition (Symbol Digit Modalities Test, SDMT), mood (Beck Depression Inventory, BDI), walking endurance (six-minute walk distance, 6MWD), walking speed (Timed Twenty-Foot Walk, T25FW), impact of MS (Multiple Sclerosis Impact Scale, MSIS-29), and anthropometric measurements (height and weight).
Aerobic reserve capacity was 9.3 ± 3.7 ml/kg/min. Aerobic reserve capacity was positively associated with VO (ρ = .67, p < .01), time to exhaustion (ρ = .63, p < .01), and SDMT (ρ = .51, p < .05). Aerobic reserve capacity was negatively associated with BMI (ρ = -.62, p < .01) and RHR (ρ = -0.47, p < .05).
We provide preliminary evidence that aerobic reserve capacity is a feasible outcome derived from maximal CPET (eg, modified Balke protocol) in MS. Aerobic reserve capacity was associated with clinically relevant outcomes and could become an important outcome for rehabilitation in future research.
有氧储备能力反映了完成日常生活任务的可用能量，它已在老年人群中进行了研究。本初步研究探讨了多发性硬化症（MS）中有氧储备能力的概念验证和测量。
21 名完全能走动的 MS 患者进行了最大心肺运动测试（CPET）。我们根据峰值有氧能力（VO ）和第一阶段耗氧量（VO ）之间的差异计算了有氧储备能力。参与者完成了残疾评估（扩展残疾状况量表，EDSS）、认知评估（符号数字模态测试，SDMT）、情绪评估（贝克抑郁量表，BDI）、步行耐力评估（六分钟步行距离，6MWD）、步行速度评估（定时 25 英尺行走测试，T25FW）、MS 影响评估（多发性硬化症影响量表，MSIS-29）和人体测量评估（身高和体重）。
有氧储备能力为 9.3±3.7ml/kg/min。有氧储备能力与 VO 呈正相关（ρ=.67，p<.01），与疲劳时间呈正相关（ρ=.63，p<.01），与 SDMT 呈正相关（ρ=.51，p<.05）。有氧储备能力与 BMI 呈负相关（ρ=-.62，p<.01），与静息心率呈负相关（ρ=-.47，p<.05）。
我们提供了初步证据，表明有氧储备能力是 MS 中最大 CPET（例如，改良 Balke 方案）得出的可行结果。有氧储备能力与临床相关结局相关，可能成为未来康复研究中重要的康复结局。
