Department of Occupational and Environmental Dermatology, Lund University, Skåne University Hospital, Malmö, Sweden.
Department of Dermatology, University Hospital Jena, Jena, Germany.
J Eur Acad Dermatol Venereol. 2021 Aug;35(8):1692-1701. doi: 10.1111/jdv.17315. Epub 2021 May 16.
In a European study on contact allergy in the general population, it has been hypothesized that the combination of contact allergy to a fragrance together with a history indicating dermatitis at exposure and thereafter subsequent avoidance of scented products implied a diagnosis of allergic contact dermatitis.
The primary aim of this study was to validate this hypothesis/algorithm. The secondary aim was to investigate whether there was any association between the outcome of the recent repeated open application test (ROAT) and the patch test reactivity.
One hundred nine subjects with and without contact allergy to fragrance mix II (FM II) were recruited. Volunteers from six European dermatology clinics participated in the study including a patch test and a ROAT.
Twenty-four positive ROAT reactions were noted in total including 20 of those 32 with contact allergy to FM II. None of the volunteers reacted to the vehicle (P < 0.001). More individuals with a positive algorithm had positive ROATs when compared with those with a negative algorithm. However, the difference was not statistically significant (P = 0.12). The lower the patch test concentration eliciting a positive test reaction, the more likely was a positive ROAT and the more likely that the positive ROAT appeared early during the investigative period.
The algorithm used in this study was not validated but it was indicated in this ROAT setup. The stronger the patch test reactivity the more likely was a positive ROAT and the more likely it was that the positive ROAT appeared early during the application period.
在一项针对普通人群接触性皮炎的欧洲研究中，有人假设，对香料的接触过敏加上暴露性皮炎病史以及此后对香味产品的回避，意味着过敏性接触性皮炎的诊断。
本研究的主要目的是验证这一假设/算法。次要目的是调查近期重复开放性应用测试（ROAT）的结果与斑贴试验反应之间是否存在任何关联。
共招募了 109 名接触或不接触香料混合物 II（FM II）的受试者。来自欧洲六个皮肤科诊所的志愿者参与了这项研究，包括斑贴试验和 ROAT。
共观察到 24 次阳性 ROAT 反应，其中 32 例接触 FM II 的患者中有 20 例阳性。没有志愿者对载体产生反应（P<0.001）。与算法阴性的志愿者相比，算法阳性的志愿者有更多的 ROAT 阳性。然而，这一差异没有统计学意义（P=0.12）。斑贴试验浓度越高，阳性反应的可能性越大，ROAT 的阳性反应出现得越早。
本研究中使用的算法未得到验证，但在 ROAT 中得到了验证。斑贴试验反应越强，ROAT 阳性的可能性越大，阳性反应在应用期出现得越早。
