Service de dermatologie et allergologie, Hôpital Tenon, Paris, France.
Service de Dermatologie, Hôpital Henri Mondor, Créteil, France.
Contact Dermatitis. 2022 Aug;87(2):170-175. doi: 10.1111/cod.14118. Epub 2022 Apr 15.
The repeated open application test (ROAT) is an adjuvant investigation measure to patch testing in the diagnosis of allergic contact dermatitis. ESCD recommends a 15 days duration but its overall duration varies according to publications and patients hardly adhere to prolonged ROAT duration beyond 1 week.
The Dermatology and Allergy Group of the French Society of Dermatology performed a prospective study with the aim of determining the best duration for the ROAT.
A total of 328 ROAT results were collected for topical products, including cosmetics (60%) and topical medications (31.1%). Fifty-nine (18%) ROATs were positive, and 16 (5%) were doubtful. All the positive ROATs occurred within 10 days, with a median time to positivity of 3 days.
According to our results, a minimum duration of 10 days is necessary to achieve a positive ROAT to a topical product.
重复开放应用测试（ROAT）是一种辅助斑贴试验的诊断变应性接触性皮炎的检测手段。欧洲接触性皮炎研究组（ESCD）建议 ROAT 的持续时间为 15 天，但根据出版物的不同，其总持续时间存在差异，且患者很难坚持超过 1 周的 ROAT 持续时间。
法国皮肤病学会皮肤病和过敏学组进行了一项前瞻性研究，旨在确定 ROAT 的最佳持续时间。
共收集了 328 份外用产品的 ROAT 结果，包括化妆品（60%）和外用药物（31.1%）。59 份（18%）ROAT 呈阳性，16 份（5%）为可疑阳性。所有阳性 ROAT 均发生在 10 天内，阳性时间中位数为 3 天。
根据我们的结果，为了获得外用产品的阳性 ROAT，最短持续时间为 10 天。
