近红外发射荧光同双核金（I）配合物，表现出有前景的体外和体内治疗性能。
Near-infrared emitting fluorescent homobimetallic gold(I) complexes displaying promising in vitro and in vivo therapeutic properties.
机构信息
ICMUB UMR6302, CNRS, Univ. Bourgogne Franche-Comté, F-21000, Dijon, France.
ICMUB UMR6302, CNRS, Univ. Bourgogne Franche-Comté, F-21000, Dijon, France; Laboratoire d'Immunologie et Immunothérapie des Cancers (LIIC, EA7269), EPHE, PSL Research, University, F-75000, Paris, France, Université de Bourgogne Franche Comté, F-21000, Dijon, France.
出版信息
Eur J Med Chem. 2021 Aug 5;220:113483. doi: 10.1016/j.ejmech.2021.113483. Epub 2021 Apr 19.
Three near-infrared (NIR-I) optical theranostic systems were synthesized, characterized and studied in vitro and in vivo. These original homo-bimetallic gold(I)-based aza-BODIPY complexes proved to be trackable through near-infrared optical imaging in cells and in mice. They display anti-proliferative properties in micromolar range against human and murine cancer cell lines (4T1, MDA-MB-231, CT26, and SW480). Moreover, the injection of the most promising theranostic agent in CT26 tumor-bearing BALB/c mice induced a significant anti-cancer activity.
三种近红外（NIR-I）光治疗诊断系统被合成、表征，并在体外和体内进行了研究。这些原始的同双金属金（I）基氮杂-BODIPY 配合物被证明可以通过细胞和小鼠中的近红外光学成像进行追踪。它们对人源和鼠源癌细胞系（4T1、MDA-MB-231、CT26 和 SW480）表现出在微摩尔范围内的抗增殖特性。此外，在 CT26 荷瘤 BALB/c 小鼠中注射最有前途的治疗诊断试剂，可诱导显著的抗癌活性。
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