Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany.
Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich Heine University Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf, Germany.
Biol Chem. 2021 Apr 29;402(9):1033-1045. doi: 10.1515/hsz-2021-0193. Print 2021 Aug 26.
Liver cell hydration (cell volume) is dynamic and can change within minutes under the influence of hormones, nutrients, and oxidative stress. Such volume changes were identified as a novel and important modulator of cell function. It provides an early example for the interaction between a physical parameter (cell volume) on the one hand and metabolism, transport, and gene expression on the other. Such events involve mechanotransduction (osmosensing) which triggers signaling cascades towards liver function (osmosignaling). This article reviews our own work on this topic with emphasis on the role of β integrins as (osmo-)mechanosensors in the liver, but also on their role in bile acid signaling.
肝细胞的水合作用（细胞体积）是动态的，可以在激素、营养物质和氧化应激的影响下在数分钟内发生变化。这种体积变化被认为是细胞功能的一种新的重要调节剂。它为物理参数（细胞体积）与代谢、运输和基因表达之间的相互作用提供了一个早期的例子。这些事件涉及机械转导（渗透感应），它触发了向肝功能（渗透信号）的信号级联。本文综述了我们在这一领域的工作，重点介绍了β整联蛋白作为（渗透）机械感受器在肝脏中的作用，但也介绍了它们在胆汁酸信号中的作用。
