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前列腺癌患者因新冠病毒疾病（COVID-19）导致的住院率和死亡率增加。

Increased Hospitalization and Mortality from COVID-19 in Prostate Cancer Patients.

作者信息

Chakravarty Dimple, Ratnani Parita, Sobotka Stanislaw, Lundon Dara, Wiklund Peter, Nair Sujit S, Tewari Ashutosh K

机构信息

Department of Urology and The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

出版信息

Cancers (Basel). 2021 Apr 1;13(7):1630. doi: 10.3390/cancers13071630.

DOI:10.3390/cancers13071630
PMID:33915795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8037308/
Abstract

BACKGROUND

Cancer patients with COVID-19 have a poor disease course. Among tumor types, prostate cancer and COVID-19 share several risk factors, and the interaction of prostate cancer and COVID-19 is purported to have an adverse outcome.

METHODS

This was a single-institution retrospective study on 286,609 patients who underwent the COVID-19 test at Mount Sinai Hospital system from March 2020 to December 2020. Chi-square/Fisher's exact tests were used to summarize baseline characteristics of categorical data, and Mann-Whitney U test was used for continuous variables. Univariable logistic regression analysis to compare the hospitalization and mortality rates and the strength of association was obtained by the odds ratio and confidence interval.

RESULTS

This study aimed to compare hospitalization and mortality rates between men with COVID-19 and prostate cancer and those who were COVID-19-positive with non-prostate genitourinary malignancy or any solid cancer, and with breast cancer patients. We also compared our studies to others that reported the incidence and severity of COVID-19 in prostate cancer patients. Our studies highlight that patients with prostate cancer had higher susceptibility to COVID-19-related pathogenesis, resulting in higher mortality and hospitalization rates. Hospitalization and mortality rates were higher in prostate cancer patients with COVID-19 when compared with COVID-19 patients with non-prostate genitourinary (GU) malignancies.

摘要

背景

新冠肺炎癌症患者的病程较差。在肿瘤类型中，前列腺癌和新冠肺炎有几个共同的风险因素，且前列腺癌与新冠肺炎的相互作用被认为会产生不良后果。

方法

这是一项单机构回顾性研究，研究对象为2020年3月至2020年12月在西奈山医院系统接受新冠肺炎检测的286,609名患者。卡方检验/费舍尔精确检验用于总结分类数据的基线特征，曼-惠特尼U检验用于连续变量。采用单变量逻辑回归分析比较住院率和死亡率，并通过比值比和置信区间得出关联强度。

结果

本研究旨在比较新冠肺炎合并前列腺癌的男性患者与新冠肺炎检测呈阳性的非前列腺泌尿生殖系统恶性肿瘤患者、任何实体癌患者以及乳腺癌患者之间的住院率和死亡率。我们还将我们的研究与其他报告前列腺癌患者中新冠肺炎发病率和严重程度的研究进行了比较。我们的研究强调，前列腺癌患者对新冠肺炎相关发病机制的易感性更高，导致更高的死亡率和住院率。与新冠肺炎合并非前列腺泌尿生殖系统（GU）恶性肿瘤的患者相比，新冠肺炎合并前列腺癌的患者的住院率和死亡率更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/b8be19451eac/cancers-13-01630-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/558b6e9f8ed4/cancers-13-01630-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/bdbf25209627/cancers-13-01630-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/8979cdb1dab7/cancers-13-01630-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/2282d0a064a6/cancers-13-01630-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/8a80dde8b606/cancers-13-01630-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/63869ce5fe63/cancers-13-01630-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/a6b40ddf3196/cancers-13-01630-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/b8be19451eac/cancers-13-01630-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/558b6e9f8ed4/cancers-13-01630-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/bdbf25209627/cancers-13-01630-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/8979cdb1dab7/cancers-13-01630-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/2282d0a064a6/cancers-13-01630-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/8a80dde8b606/cancers-13-01630-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/63869ce5fe63/cancers-13-01630-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/a6b40ddf3196/cancers-13-01630-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f62a/8037308/b8be19451eac/cancers-13-01630-g008.jpg

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