Nieciecka Dorota, Celej Joanna, Żuk Michał, Majkowska-Pilip Agnieszka, Żelechowska-Matysiak Kinga, Lis Antoni, Osial Magdalena
Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093 Warsaw, Poland.
Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 Str., 03-195 Warsaw, Poland.
Pharmaceutics. 2021 Apr 1;13(4):480. doi: 10.3390/pharmaceutics13040480.
Cancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.
癌症是全球最常见的死因之一，因此抗癌治疗的新解决方案备受追捧。在这项工作中，合成了与抗癌药物共轭的超顺磁性氧化铁纳米颗粒（SPIONs），并将其作为用于局部药物递送和温和磁热疗的潜在磁性药物纳米载体进行了研究。我们获得了一种负载钬和抗癌药物的混合系统，并对其尺寸、形态、表面修饰和磁性、与生物膜模型的相互作用以及细胞毒性进行了全面研究。我们展示了具有圆形形状和15纳米尺寸的纳米颗粒成功地得到了稳定，以避免其团聚，并以可控方式用阿霉素或表柔比星进行了修饰。通过热重分析法确定了负载到SPIONs中的药物数量。基于SPIONs的混合物在Langmuir-Blodgett技术下与模型生物膜接触进行了研究，结果表明修饰后的SPION与它们有效地相互作用。磁热疗和生物学研究获得的结果证实了该混合物在未来癌细胞治疗方面具有前景的特性。
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