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载有多柔比星的多功能氧化铁纳米颗粒在MEC1和RM1细胞系中的特性及抗肿瘤活性

Characteristics and Antitumor Activity of Doxorubicin-Loaded Multifunctional Iron Oxide Nanoparticles in MEC1 and RM1 Cell Lines.

作者信息

Maisuradze Nino, Kekutia Shalva, Markhulia Jano, Tsertsvadze Tamar, Mikelashvili Vladimer, Saneblidze Liana, Chkhaidze Nikoloz, Horváth Zsolt Endre, Almásy László, Mitskevichi Nunu

机构信息

Division of Immunology and Microbiology, Iv. Javakhishvili Tbilisi State University, 1, Ilia Tchavchavadze Ave., 0179 Tbilisi, Georgia.

Nanocomposites Laboratory, Vladimer Chavchanidze Institute of Cybernetics of the Georgian Technical University, Z. Anjafaridze Str. 5, 0186 Tbilisi, Georgia.

出版信息

J Funct Biomater. 2024 Dec 3;15(12):364. doi: 10.3390/jfb15120364.

DOI:10.3390/jfb15120364
PMID:39728164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676272/
Abstract

The rapid progress in nanotechnology has introduced multifunctional iron oxide nanoparticles as promising agents in cancer treatment. This research focused on the synthesis and assessment of citric-acid-coated, folic-acid-conjugated nanoparticles loaded with doxorubicin, evaluating their therapeutic potential in tumor models. An advanced automated continuous technology line (CTL) utilizing a controlled co-precipitation method was employed to produce highly dispersive, multifunctional nanofluids with a narrow size distribution. Various techniques, including dynamic light scattering (DLS), electrophoretic light scattering (ELS), X-ray diffraction (XRD), and transmission electron microscopy (TEM), were employed to examine the particle size, zeta potential, structure, and morphology. Magnetic properties were analyzed through vibrating sample magnetometry (VSM), and surface modifications were confirmed via UV-visible (UV-Vis) and Fourier-Transform Infrared (FTIR) spectroscopy. Cytotoxicity and drug delivery efficiency were evaluated in vitro using RM1 (prostate cancer) and MEC1 (chronic lymphocytic leukemia) cell lines. Fluorescence microscopy demonstrated the successful intracellular delivery of doxorubicin, showcasing the nanoparticles' potential for targeted cancer therapy. However, folic-acid-conjugated nanoparticles exhibited diminished effectiveness over time. This study highlights the importance of nanoparticle optimization for enhancing therapeutic performance. Further research should aim to improve nanoparticle formulations and explore their long-term impacts for the development of safe, targeted cancer treatments.

摘要

纳米技术的快速发展已将多功能氧化铁纳米颗粒引入癌症治疗领域，成为有前景的治疗手段。本研究聚焦于合成并评估负载阿霉素的柠檬酸包覆、叶酸共轭纳米颗粒，并在肿瘤模型中评估其治疗潜力。采用先进的自动化连续技术生产线（CTL），利用可控共沉淀法制备出具有高分散性、窄尺寸分布的多功能纳米流体。采用多种技术，包括动态光散射（DLS）、电泳光散射（ELS）、X射线衍射（XRD）和透射电子显微镜（TEM），来检测颗粒大小、zeta电位、结构和形态。通过振动样品磁强计（VSM）分析磁性特性，并通过紫外可见（UV-Vis）光谱和傅里叶变换红外（FTIR）光谱确认表面修饰。使用RM1（前列腺癌）和MEC1（慢性淋巴细胞白血病）细胞系在体外评估细胞毒性和药物递送效率。荧光显微镜显示阿霉素成功实现细胞内递送，展示了纳米颗粒在靶向癌症治疗方面的潜力。然而，随着时间推移，叶酸共轭纳米颗粒的有效性逐渐降低。本研究强调了优化纳米颗粒以提高治疗性能的重要性。进一步的研究应致力于改进纳米颗粒制剂，并探索其长期影响，以开发安全、靶向的癌症治疗方法。

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本文引用的文献

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2
A Promising Approach: Magnetic Nanosystems for Alzheimer's Disease Theranostics.一种有前景的方法：用于阿尔茨海默病诊疗的磁性纳米系统。
Pharmaceutics. 2023 Sep 13;15(9):2316. doi: 10.3390/pharmaceutics15092316.
3
Targeted Doxorubicin-Loaded Dendronized Gold Nanoparticles.靶向载有阿霉素的树枝状金纳米颗粒。
Pharmaceutics. 2023 Aug 9;15(8):2103. doi: 10.3390/pharmaceutics15082103.
4
Advances of medical nanorobots for future cancer treatments.医学纳米机器人在未来癌症治疗中的进展。
J Hematol Oncol. 2023 Jul 14;16(1):74. doi: 10.1186/s13045-023-01463-z.
5
Synthesis, Characterization, and In Vitro Cytotoxicity Evaluation of Doxorubicin-Loaded Magnetite Nanoparticles on Triple-Negative Breast Cancer Cell Lines.载阿霉素磁性纳米颗粒对三阴性乳腺癌细胞系的合成、表征及体外细胞毒性评价
Pharmaceutics. 2023 Jun 17;15(6):1758. doi: 10.3390/pharmaceutics15061758.
6
Ibrutinib and rituximab versus fludarabine, cyclophosphamide, and rituximab for patients with previously untreated chronic lymphocytic leukaemia (FLAIR): interim analysis of a multicentre, open-label, randomised, phase 3 trial.伊布替尼联合利妥昔单抗与氟达拉滨、环磷酰胺和利妥昔单抗治疗初治慢性淋巴细胞白血病患者（FLAIR）：一项多中心、开放标签、随机、3 期临床试验的中期分析。
Lancet Oncol. 2023 May;24(5):535-552. doi: 10.1016/S1470-2045(23)00144-4.
7
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