Oliveira Melina de Moraes Santos, Salgado Carla de Moraes, Viana Lais Rosa, Gomes-Marcondes Maria Cristina Cintra
Nutrition and Cancer Laboratory, Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Sao Paulo 13083-862, Brazil.
Cancers (Basel). 2021 Apr 1;13(7):1667. doi: 10.3390/cancers13071667.
Cancer during pregnancy is rarely studied due to its low incidence (1:1000). However, as a result of different sociocultural and economic changes, women are postponing pregnancy, so the number of pregnant women with cancer has been increasing in recent years. The importance of studying cancer during pregnancy is not only based on maternal and foetal prognosis, but also on the evolutionary mechanisms of the cell biology of trophoblasts and neoplastic cells, which point out similarities between and suggest new fields for the study of cancer. Moreover, the magnitude of how cancer factors can affect trophoblastic cells, and vice versa, in altering the foetus's nutrition and health is still a subject to be understood. In this context, the objective of this narrative review was to show that some researchers point out the importance of supplementing branched-chain amino acids, especially leucine, in experimental models of pregnancy associated with women with cancer. A leucine-rich diet may be an interesting strategy to preserve physiological placenta metabolism for protecting the mother and foetus from the harmful effects of cancer during pregnancy.
由于孕期癌症发病率较低（1:1000），对其研究较少。然而，由于不同的社会文化和经济变化，女性推迟生育，因此近年来患癌孕妇的数量一直在增加。研究孕期癌症的重要性不仅基于母婴预后，还基于滋养层细胞和肿瘤细胞的细胞生物学进化机制，这些机制指出了两者之间的相似性，并为癌症研究提出了新领域。此外，癌症因素如何影响滋养层细胞，反之亦然，从而改变胎儿营养和健康的程度仍是一个有待了解的问题。在此背景下，本叙述性综述的目的是表明一些研究人员指出，在与患癌女性相关的妊娠实验模型中补充支链氨基酸，尤其是亮氨酸具有重要意义。富含亮氨酸的饮食可能是一种有趣的策略，可维持胎盘生理代谢，以保护母亲和胎儿在孕期免受癌症的有害影响。
