Nölle B, Gross W L
Abteilung Allgemeine Innere Medizin, Universität, Kiel.
Immun Infekt. 1988 Apr;16(2):68-70.
Antibodies against cytoplasmic structures of neutrophilic granulocytes and monocytes (ACPA) are highly specific for Wegener's granulomatosis (WG). We found 77 out of 105 patients suffering from clinically and histologically proven WG seropositive for ACPA, whereas only 8 patients out of 123 other vasculitides showed ACPA, too. Of those were 3 cases out of 20 with panarteritis nodosa and 5 patients out of 51 with unclassified systemic vasculitides. About half of the patients showed systemic inflammatory activity with respect to C-reactive protein values above 10 mg/l at time of serum sampling.
抗中性粒细胞和单核细胞胞质结构抗体（ACPA）对韦格纳肉芽肿（WG）具有高度特异性。我们发现，105例经临床和组织学证实为WG的患者中，有77例ACPA血清学呈阳性，而123例其他血管炎患者中只有8例也显示ACPA阳性。其中，结节性多动脉炎20例中有3例，未分类的系统性血管炎51例中有5例。大约一半的患者在血清采样时C反应蛋白值高于10mg/l，显示有全身炎症活动。
