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加纳急性营养不良中 MUAC 预测因素的确定模型。

A Model for Determining Predictors of the MUAC in Acute Malnutrition in Ghana.

机构信息

Senior Research Fellow, Centre for Social Science Research, Kumasi Technical University, Kumasi 854, Ghana.

Biomedical Scientist, Department of Laboratory Technology, Kumasi Technical University, Kumasi 854, Ghana.

出版信息

Int J Environ Res Public Health. 2021 Apr 5;18(7):3792. doi: 10.3390/ijerph18073792.

DOI:10.3390/ijerph18073792
PMID:33916468
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8038631/
Abstract

The issue of malnutrition is perhaps the most important public health determinant of global wellbeing. It is one of the main causes of improper mental and physical development as well as death of many children. The Mid Upper Arm Circumference (MUAC) rapid text setup is able to diagnose malnutrition due to the fact that the human arm contains subcutaneous fat and muscle mass. When proportional food intake increases or reduces, the corresponding increase or reduction in the subcutaneous fat and muscle mass leads to an increase or decrease in the MUAC. In this study, the researchers attempt to develop a model for determining the performance of MUAC in predicting Child malnutrition in Ghana. It focuses on the Joint Generalized Linear Model (Joint-GLM) instead of the traditional Generalized Linear Model (GLM). The analysis is based on primary data measured on children under six years, who were undergoing nutritional treatment at the Princess Marie Louise (PML) Children's Hospital in the Ashiedu Keteke sub-metro area of Accra Metropolis. The study found that a precisely measured weight of a child, height, and albumen levels were positive determinants of the predicted MUAC value. The study also reveals that, of all the variables used in determining the MUAC outcome, the hemoglobin and total protein levels of a child would be the main causes of any variation between the exact nutritional status of a child and that suggested by the MUAC value. The final Joint-GLM suggests that, if there are occasions where the MUAC gave false results, it could be a result of an imbalance in the child's hemoglobin and protein levels. If these two are within acceptable levels in a child, the MUAC is most likely to be consistent in predicting the child's nutritional status accurately. This study therefore recommends the continued use of MUAC in diagnosis of child malnutrition but urges Ghana and countries in Sub-Saharan Africa to roll out an effective nutrition intervention plan targeting the poor and vulnerable suburbs so that the nutritional status of children under five years of age, who were the focus of the current study, may be improved.

摘要

营养不良问题或许是全球福祉最重要的公共卫生决定因素。它是造成许多儿童发育不良、身体和精神受损乃至死亡的主要原因之一。中臂围(MUAC)快速检测法能够诊断营养不良,因为人类手臂含有皮下脂肪和肌肉。当食物摄入相应增加或减少时,皮下脂肪和肌肉量的增减会导致 MUAC 的增减。在这项研究中,研究人员试图建立一个模型,用于确定 MUAC 在预测加纳儿童营养不良方面的表现。它侧重于联合广义线性模型(Joint-GLM)而不是传统的广义线性模型(GLM)。该分析基于在阿希耶杜·凯泰克(Ashiedu Keteke)阿克拉都会区的玛丽·路易丝公主(Princess Marie Louise)儿童医院接受营养治疗的 6 岁以下儿童的原始数据进行。研究发现,儿童的精确体重、身高和白蛋白水平是预测 MUAC 值的正决定因素。该研究还表明,在用于确定 MUAC 结果的所有变量中,儿童的血红蛋白和总蛋白水平将是儿童实际营养状况与 MUAC 值建议之间差异的主要原因。最终的联合广义线性模型表明,如果 MUAC 出现错误结果,可能是由于儿童的血红蛋白和蛋白水平失衡所致。如果这两个水平在儿童体内处于可接受的范围内,那么 MUAC 就很可能在准确预测儿童营养状况方面保持一致。因此,该研究建议继续使用 MUAC 诊断儿童营养不良,但敦促加纳和撒哈拉以南非洲国家推出一项针对贫困和弱势郊区的有效营养干预计划,以便改善当前研究重点关注的 5 岁以下儿童的营养状况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/d1f333ee925b/ijerph-18-03792-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/0e9058afeb61/ijerph-18-03792-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/7c8c17d3ba1a/ijerph-18-03792-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/d1f333ee925b/ijerph-18-03792-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/0e9058afeb61/ijerph-18-03792-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/7c8c17d3ba1a/ijerph-18-03792-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d70/8038631/d1f333ee925b/ijerph-18-03792-g003.jpg

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本文引用的文献

1
Current MUAC Cut-Offs to Screen for Acute Malnutrition Need to Be Adapted to Gender and Age: The Example of Cambodia.当前用于筛查急性营养不良的中上臂围切点需要根据性别和年龄进行调整:以柬埔寨为例。
PLoS One. 2016 Feb 3;11(2):e0146442. doi: 10.1371/journal.pone.0146442. eCollection 2016.
2
Comparison of Clinical Characteristics and Treatment Outcomes of Children Selected for Treatment of Severe Acute Malnutrition Using Mid Upper Arm Circumference and/or Weight-for-Height Z-Score.使用上臂中部周长和/或身高别体重Z评分选择治疗重度急性营养不良儿童的临床特征和治疗结果比较
PLoS One. 2015 Sep 16;10(9):e0137606. doi: 10.1371/journal.pone.0137606. eCollection 2015.
3
Comparison of weight-for-height and mid-upper arm circumference (MUAC) in a therapeutic feeding programme in South Sudan: is MUAC alone a sufficient criterion for admission of children at high risk of mortality?
南苏丹一项治疗性喂养项目中身高别体重与上臂中部周长(MUAC)的比较:仅MUAC是否足以作为收治高死亡风险儿童的标准?
Public Health Nutr. 2015 Oct;18(14):2575-81. doi: 10.1017/S1368980015000737. Epub 2015 Mar 25.
4
Optimal screening of children with acute malnutrition requires a change in current WHO guidelines as MUAC and WHZ identify different patient groups.对患有急性营养不良的儿童进行最佳筛查需要改变世界卫生组织目前的指导方针,因为上臂围(MUAC)和身高别体重(WHZ)所识别的患者群体不同。
PLoS One. 2014 Jul 1;9(7):e101159. doi: 10.1371/journal.pone.0101159. eCollection 2014.
5
Is mid-upper arm circumference alone sufficient for deciding admission to a nutritional programme for childhood severe acute malnutrition in Bangladesh?仅用上臂中部周径是否足以决定孟加拉国儿童严重急性营养不良入院营养方案?
Trans R Soc Trop Med Hyg. 2013 May;107(5):319-23. doi: 10.1093/trstmh/trt018. Epub 2013 Mar 6.
6
Mid-upper arm circumference based nutrition programming: evidence for a new approach in regions with high burden of acute malnutrition.基于中上臂围的营养规划:在急性营养不良负担高的地区采用新方法的证据。
PLoS One. 2012;7(11):e49320. doi: 10.1371/journal.pone.0049320. Epub 2012 Nov 26.
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Management of severe acute malnutrition in children.儿童重度急性营养不良的管理
Lancet. 2006 Dec 2;368(9551):1992-2000. doi: 10.1016/S0140-6736(06)69443-9.
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A review of methods to detect cases of severely malnourished children in the community for their admission into community-based therapeutic care programs.关于在社区中检测重度营养不良儿童病例以便其纳入社区治疗护理项目的方法综述。
Food Nutr Bull. 2006 Sep;27(3 Suppl):S7-23. doi: 10.1177/15648265060273S302.
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Precision of anthropometric measurements: the value of mid-arm circumference.人体测量的精度:上臂中部周长的价值。
Clin Nutr. 1984 Mar;2(3-4):193-6. doi: 10.1016/0261-5614(84)90025-6.
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JAMA. 2005 Aug 3;294(5):591-7. doi: 10.1001/jama.294.5.591.